LITLHAHISO: Boithuto ke bona ba pele ba ho senola kamoo oxytocin e ka thibelang mekhoa ea ho lemalla lithethefatsi. Ho netefalitsoe hantle hore oxytocin e fokotsa litakatso le ts'ebeliso ea lithethefatsi liphoofolong tse lemaletseng lintho tse ling. Ho boetse ho netefalitsoe hore oxytocin ea putsa ebile e kenya ts'ebetsong dopamine ho potoloho ea moputso. Phuputso ena e na le oxytocin e thibelang dopamine le boits'oaro bo lemalloang moahong o monyane haholo oa potoloho
mohloli o moholo
Lefapha la Psychology, Univesithi ea Macquarie, Sydney, Australia.
inahaneloang
Subthalamic nucleus (STh) e ntse e amoheloa ka ho eketsehileng e le sebaka sa bohlokoa se kenyelletsoeng molemong oa moputso oa lithethefatsi. Ha e e-so tsejoe haeba dopamine, neurotransmitter e ikarabellang haholo bakeng sa ho saena moputso, e boetse e kenella ho arolelanang mesebetsi e amanang le moputso ho STh. Neuropeptide oxytocin e sebetsa kahare ho STh ho fokotsa litlamorao tse atlehang tsa psychostimulant methamphetamine, ka ts'ebelisano e kopaneng le dopamine. Le ha ho le joalo, mekhoa ea ts'ebelisano ena ha e hlake. Boithuto ba hajoale bo ikemiselitse ho fumana hore na-
(i) dopamine microinjected ho STh e tla etsa hore ho khethoe sebaka se seholo kamora seboka sa boemo bo le bong,
(ii) motsoako o kopanetsoeng oa dopamine receptor antagonist o ka thibela ho theoa ha sebaka se khethiloeng sa boikhethelo (CPP) bakeng sa dopamine,
iii) oxytocin e sebelisitsoeng hantle e ka thibela CPP bakeng sa dopamine le
(iv) hore na oxytocin antagonist ea khethileng desGly-NH2, d (CH2)5[D-Tyr2, Sup4] OVT, ha e sebelisana hantle le oxytocin le dopamine, e ne e tla fetola litlamorao tsa oxytocin mme e hlahise CPP bakeng sa dopamine.
Liphetho li bontšitse hore likhoto tsa banna tsa Sprague Dawley i) li thehile khetho bakeng sa moelelo o kopantsoeng le taolo ea dopamine (100 nmol / lehlakoreng) ho STh, e neng e thibetsoe ke ts'ebelisano-'moho ea ii) motsoako o kopaneng oa dopamine antagonist fluphenazine (10 nmol / lehlakoreng) kapa iii) oxytocin (0.6 nmol / lehlakoreng), le phello ea oxytocin ho dopamine CPP e khutliselitsoeng morao ke ts'ebelisano 'moho ea mohanyetsi oa oxytocin (3 nmol / lehlakoreng). Tdata ea hese e fana ka maikutlo a hore dopamine neurotransication ho STh e hlahisa litlamorao tse ka fokotsang ka ts'ebetso ea li-oxytocin receptors tsa lehae.
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