Maikutlo: Bo-rasaense ba theotse dopamine ho mohlankana ea phetseng hantle. O ile a ba le matšoao a sa tšoaneng. Batho ba lemaletseng bootsoa ba atisa ho ba le matšoao a tšoanang (kapa liphetolelo tse bonolo haholoanyane) nakong ea ho tlohela, kapa pakeng tsa mananeo a bootsoa. Matšoao a ka hlaha ka lebaka la ho fetoha ha maemo a dopamine receptor hammoho le dopamine e tlase.
Am J Psychiatry 162: 1755, Loetse 2005 doi: 10.1176 / appi.ajp.162.9.1755 © 2005 American Psychiatric Association
LIEUWE de HAAN, MD, PH.D., JAN BOOIJ, MD, PH.D., JULES LAVALYE, MD, PH.D., T. van AMELSVOORT, MD, PH.D., le DON LINSZEN, MD, PH .D. Amsterdam, Netherlands
Ho Mohlophisi: Paradigm e etsang hore motho a felloe ke matla le ho feta ka lithethefatsi. Mona re hlalosa boiphihlelo bo makatsang ba maiketsetso bo susumetsoang ke khatello e matla ea dopamine ho moithaopi a le mong ea phetseng hantle. Li kenyelelitse letšoao le akaretsang la matšoao a kelello 'me la totobatsa tlatsetso ea sisteme ea dopaminergic ho mafu a maholo a fapaneng a kelello.
Thutong ea rona, dopamine depletion e fihlelitsoe ka tsamaiso ea molomo ea 4.5 g AMPT ka lihora tsa 25, joalo ka ha ho hlalositsoe pejana (1). Li-receptor tsa Striatal D2 li ile tsa hlahlojoa ho latela motheo le ka mor'a ho fokotseha ho matla ha dopamine ka ho sebelisa bolus / infusion ea kamehla [123I] IBZM mokhoa (1). Ho fumana, ho aha bocha le ho hlahloba data e le 'ngoe ea "photon emissions" e entsoeng ka mokhoa o ikhethileng e entsoe joalo ka ha ho hlalositsoe pele (2).
Mong A e ne e le seithuti sa bongaka se phetseng hantle, se eketsehileng, se sebetsang hantle sa 21 ea lilemo li ngata ntle le mathata a fokolang a kelello kapa mathata a kelello lelapeng la hae. Tlhahlobo ea hae ea Global Global of Functioning Scale score e ne e le 97. Ho ile ha fumaneha tumello e ngotsoeng ho Monghali A. Re tla hlalosa lipono tse itlhahelang feela ka mor'a hore a qale ho sebelisa tekanyetso ea pele ea 750 mg AMPT ka lihora tse X =UMX (0).
Kamora lihora tsa 7, Mong A o ile a ikutloa a le hole le eena le tikoloho ea hae. Stimuli e bile le tshusumetso e fokolang; maikutlo a hlakileng le a utloisisang a ne a se bohale haholo. O ile a felloa ke tšusumetso le mokhathala. Kamora lihora tsa 18, o ile a ba le bothata ba ho tsoha le mokhathala o eketsehileng; maemo a tikoloho a ne a bonahala a le lerootho. O ne a sa bue ka mokhoa o phollatsi. Kamora lihora tsa 20, o ile a ikutloa a ferekane. O ne a ikutloa a tsitsipane pele ho nako ea hae mme o ne a e-na le takatso ea ho sheba oache ea hae ka tsela e hlokolosi.
Kamora lihora tsa 24, Mong A o ile a hloka botsitso kahare, sefofane sa mehopolo; mehopolo ea hae e ne e utloahala e thetsitsoe, 'me o ne a sa e hopole. O ile a ikutloa a felloa ke matla a ho laola maikutlo a hae. Kamora lihora tsa 28, o ile a ikutloa a le lihlong, a tšohile, a tšoenyehile a bile a sithabetse maikutlo. O ne a tšaba hore boemo bo tla tsoela pele. Ka nako eo, blepharospasm, sefahleho sa mask le ho thothomela li ile tsa hlokomeloa. Kamora lihora tsa 30, o ne a khathetse mme a robala lihora tsa 11. Kamora lihora tsa 42, o bile le khatello e mpe ea kelello. Lihora tse latelang, o ile a khutlela ho tloaelehileng.
Tekanyo e tlamang ea striatal-to-nonspecific e ne e le 27% e phahame ka mor'a hore Mong A a nke AMPT ha a bapisoa le boemo ba motheo, a bonts'a ho fokola haholo ha dopamine depletion (1).
Nakong ea ho fokola ha dopamine ntlheng ena, liphihlelo tse fapaneng tsa subjential li ile tsa hlaha mme tsa nyamela ka ho latellana. Liphihlelo tsena li ne li tšoana le matšoao a seng matle, matšoao a bonoang, likhatello tsa monahano, le matšoenyeho le matšoao a sithabetsang mme li totobatsa bohlokoa ba karolo ea dopamine mathateng a maholo a kelello. Lithutong tsa pele, AMPT e fumanoe e theola moea, ho tepella maikutlo, ho fokotsa tlhokomeliso ea, le / kapa ho ts'oants'a matšoao a extrapyramidal ho batho ba bang ba phetseng hantle (e hlahlojoa ho ea boletsoeng 3).
Kaha liphihlelo tse tlatselletsang ka lebaka la ho fokola ha dopamine li ka ba matla haholo, re lumela hore lithuto tse nkang karolo lithutong tsa dopamine-depletion li lokela ho tsebisoa hantle ka litlamorao tsa nakoana — empa tse matla.
References
1. Verhoeff NP, Kapur S, Hussey D, Lee M, Christensen B, Papatheodorou G, Zipursky RB: Mokhoa o bonolo oa ho lekanya ho lula ha li-dostamine tsa DostNatX tsa dostamine ka dopamine ho vivo lithutong tse phetseng hantle. Neuropsychopharmacology 2; 2001: 25-213 [CrossRef] [Medline]
2. Booij J, Korn P, Linszen DH, van Royen EA: Tlhahlobo ea tlhahiso ea dopamine ea endo native ka phephetso ea methylphenidate ho sebelisa iodine-123 iodobenzamide single-Photon emission tomography. Eur J Nucl Med 1997; 24: 674-677 [Medline]
3. Booij L, Van der Do AJ, Riedel WJ: Monoamine depletion maemong a kelello le a phetseng hantle. Mol Psychiatry 2003; 8: 951-973 [CrossRef] [Medline]
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