Seoa sa Tlhekefetso ea Lithethefatsi le Lithethefatsi: Ho Khetholla Dopamine Homeostasis (2017)

Curr Pharm Des. 2017 Aug 22. Doi: 10.2174 / 1381612823666170823101713.

Blum K1, Thanos PK2, Wang GJ3, Febo M1, Demetrovics Z4, Modestino EJ5, Braverman ER6, Baron D6, Badgaiyan RD7, MS khauta8.

inahaneloang

Botenya bo senya bophelo ba batho ba fetang limilione tse 300 lefats'eng ka bophara mme ho boloka boima ba 'mele bo botle ho sebelisa maqheka a tsebahalang a ho theola boima ba' mele e ntse e le mosebetsi o thata haholo. Ho sebetsana le bothata ba botenya ho bonahala ho ka fihlelleha, joalo ka ha kutloisiso e ntlafala, ea ts'ebetso ea genome ea rona likarabong tsa lithethefatsi / limatlafatsi. Maano a bonts'itsoeng ke kutloisiso ena ea phepo ea phepo ea 'mele le neurogenetics kalafo le thibelo ea ts'oaetso ea metabolism le botenya a kenyelletsa ho lekanyetsa polelo ea mRNA ka DNA methylation, le thibelo ea histone deacetylation. Ho ipapisitsoe le liphatsa tsa lefutso tsa motho tse haelloang ke mekhoa ea ts'oaetso e ka lebisoa ho epigenetically ke, mohlala, phepelo ea tlatsetso ea phepo e kenyeletsang likhemik'hale tsa livithamini, livithamini le li-amino acid tsa bohlokoa. Hape, sebopeho sa chromatin sa liphatsa tsa lefutso tse hatisitsoeng tse laolang limatlafatsi nakong ea kholo ea lesea se ka fetoloa. Litsela tse amang pontšo ea dopamine, lipalangoang tsa limolek'hule le nts'etsopele ea sistimi ea methapo li amehile mekhoeng ena. Botenya ke karoloana ea Reward Deficiency Syndrome (RDS) mme maano ana a macha a kalafo le thibelo ea botenya a ntlafalitse ts'ebetso ea dopamine. Hase feela taba ea ho tšoaea mala ho amanang le li-peptide tsa hypothalamic, empa ka mokhoa o mong, ho fumana mekhoa e mecha ea ho ntlafatsa tšebetso ea ventral tegmental area (VTA) dopaminergic function le homeostasis.

LIHLOOHO: Ho lemalla lijo le lithethefatsi; epigenetics. ; hypothalamic-gut-axis; neurogenetics; taolo ea pro-dopamine; lefu la khaello ea moputso (RDS)

PMID: 28831923

DOI: 10.2174/1381612823666170823101713