Neuropharmacology. 2012 Jul 11.
mohloli o moholo
Lefapha la Psychology, Univesithi ea Wisconsin, 1202 W. Johnson St., Madison, WI 53706, USA.
inahaneloang
Lithethefatsi tse sebelisetsoang ho sebetsana le bothata ba khatello ea maikutlo (ADHD) li ntlafatsa ts'ebetso ea boits'oaro e ikemetseng ea prefrontal cortex (PFC). Bongata ba kalafo e amanang le ADHD e sebetsa joalo ka norepinephrine (NE) le dopamine (DA) reuptake inhibitors (psychostimulants) kapa NE reuptake inhibitors (SNRIs). Lipapiso tse ling tsa benztropine li sebetsa joalo ka li-reuptake inhibitors tse khethiloeng haholo tsa DA ha li ntse li haelloa ke liketso tse matlafatsang, ka hona li hlekefetsa bokhoni ba li-psychostimulants. Ho lekola tšebeliso e ka bang teng ea metsoako ena kalafong ea ADHD, re hlahlobile litlamorao tsa analogen e tsebahalang ea benztropine, AHN 2-005, ts'ebetsong ea likhoto ho ts'ebetso ea ts'ebetso ea ho lieha ho fetoha ea mohopolo oa PFC. Ho ts'oana le se bonoang ka lithethefatsi tsohle tse lumelletsoeng ADHD, ts'ebetso e ntlafalitsoeng ea tekanyetso ea AHN 2-005 mosebetsing ona. Litekanyo tse amanang le bongaka tsa li-psychostimulants le SNRIs li phahamisa NE le DA ka ho khetheha ho PFC. Leha ho na le khetho ea setsi sena bakeng sa morekisi oa DA, lithuto tse ling tsa microdialysis li bonts'itse hore tekanyetso e matlafatsang ts'oaetso ea AHN 2-005 e haelloang ke litlamorao tsa ts'ebetso ea motlakase e eketsehile maemo a kantle ho lisele tsa DA le NE ho PFC. AHN 2-005 e hlahisitse keketseho e kholo ho li-extracellular DA ho li-nucleus accumbens, leha boholo ba sena bo ne bo le ka tlase ho bo bonoang ka methati e sebelisang li-psychostimulants. Ka kakaretso, liphuputso tsena li fana ka maikutlo a hore li-analog tsa benztropine li ka sebetsa hantle kalafong ea ADHD kapa mathata a mang a amanang le ho se sebetse ha PFC. Lithuto tsena li fana ka mabaka a matla bakeng sa lipatlisiso tsa nako e tlang tse shebaneng le mekhoa ea methapo e tlatsetsang liketsong tse matlafatsang kamohelo le ts'ebeliso ea bongaka ea AHN 2-005 le metsoako e amanang le eona. Sengoloa sena ke karolo ea Taba e Khethehileng e bitsoang 'Cognitive Enhancers'.
Copyright © 2012 Elsevier Ltd. Litokelo tsohle li bolokiloe.
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