Mol Psychiatry. 2011 Nov;16(11):1147-54. doi: 10.1038/mp.2010.97.
Volkow ND, Wang GJ, New JK J, Kollins SH, Wigal TL, Telang F, JS Fowler, Goldstein RZ, Klein N, Logan J, Wong C, Swanson JM.
mohloli o moholo
Setsi sa Naha sa Tlhekefetso ea Lithethefatsi, Bethesda, MD 20892, USA. [imeile e sirelelitsoe]
inahaneloang
Boloetse ba khatello ea maikutlo (ADHD) bo tsejoa e le bothata ba ho se tsotelle le ho se tsotelle / ho se tsotelle empa ho na le bopaki bo ntseng bo eketseha ba likhaello molemong oa tšusumetso. Re sebelisa positron emission tomography (PET), re bonts'itse ts'ebetso e fokotsehileng bokong ba dopamine moputso oa tsela ho batho ba baholo ba nang le ADHD, eo re nahanang hore e ka theola likhaello tsa tšusumetso bothateng bona. Ho lekola khopolo-taba ena, re ile ra etsa litlhahlobo tsa bobeli ho lekola khokahano lipakeng tsa mehato ea PET ea dopamine D2 / D3 receptor le dopamine transporter e fumanehang (e fumanoeng ka [(11) C] raclopride le [(11) C] cocaine, ka ho latellana) ho dopamine moputso pathway (midbrain le nucleus accumbens) le surrogate ea tšusumetso ea tšobotsi (e hlahlojoang ho sebelisoa sekala sa Achievement ho Multidimensional Personality Questionnaire kapa MPQ) ho barupeluoa ba 45 ADHD le taolo ea 41. Sekhahla sa Katleho se ne se le tlase ho bankakarolo ba ADHD ho feta ho taolo (11 ± 5 vs 14 ± 3, P <0.001) mme e ne e hokahane haholo le li-receptor tsa D2 / D3 (accumbens: r = 0.39, P <0.008; midbrain: r = 0.41, P <0.005) le bapalami (accumbens: r = 0.35, P <0.02) ho bankakarolo ba ADHD, empa eseng taolong. Barupeluoa ba ADHD le bona ba ne ba na le litekanyetso tse tlase ho Constraint factor le litekanyetso tse holimo ho Negative Emotionality factor ea MPQ empa ha ea ka ea fapana ho Positive Emotionality factor-mme ha ho le e 'ngoe ea tsona e neng e amana le mehato ea dopamine. Ho barupeluoa ba ADHD, lintlha tsa sekhahla sa Katleho le tsona li ne li amana hampe le matšoao a ho se natse (CAARS A, E le SWAN I). Liphuputso tsena li fana ka bopaki ba hore ho senyeha ha tsela ea moputso oa dopamine ho amahanngoa le likhaello tsa tšusumetso ho batho ba baholo ba ADHD, tse ka kenyang letsoho khaellong ea tlhokomelo le ho ts'ehetsa ts'ebeliso ea mehato ea kalafo ho matlafatsa tšusumetso ho ADHD.
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