mohloli o moholo
Lefapha la Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. [imeile e sirelelitsoe]
inahaneloang
Patlisiso mabapi le botebo ba tlhaho ea tlhaho e ka fana ka tataiso ea pathophysiology ea mafu a kelello. Haholo-holo likarolo tsa boitšoaro tsa motho ke bothata bo tloaelehileng nakong ea bokuli ba kelello. APatlisiso e nyane e bontšitse karolo bakeng sa sisteme ea dopamine boits'oarong ba sechaba, 'me liphuputso tsa morao-rao tsa ho nahana ka limolek'hule li bontšitse khokahano e mpe pakeng tsa dopamine D2-receptor e tlamang ho striatum le ho lakatsa ha sechaba. Mekha ea maikutlo le ea kelello ea boits'oaro ba sechaba e fana ka maikutlo a ho kenyelletsa likarolo tsa boko ka ntle ho striatum, joalo ka sebopeho sa maotos. Morero oa thuto e teng hona joale e ne e le ho lekola likamano lipakeng tsa sebopeho sa botho le litakatso tsa dopamine D2-receptor tse kopanyang likarolo tsa boko le tsa boteng. Re ile ra hlahloba lithuto tsa taolo ea 16 ka Positron Emission Tomography le radioligands [(11) C] raclopride le [(11) C] FLB 457, mabapi le takatso ea kahisano ho univesithi ea Sweden Scales of botho. [(11) C] raclopride D2-receptor binding striatum e bonts'itse likamano tse mpe lipapatsong tsa desirability ea sechaba, e lumellanang le liphetho tsa pejana. Ntle le moo, ho ile ha bontšoa ntlafatso ea bohlokoa ba lipalo tse phahameng bakeng sa [(11) C] FLB 457 e tlamang mochini oa hippocampal-amygdala. Tlhahlobo e arohaneng ea lintho tse lakatsehang sechabeng mabapi le mofuta oa boitšoaro ba batho e bonts'a hore mekhatlo e ne e tsamaisoa ke lintho tse bonts'ang boikokobetso bo phahameng le kamano e phahameng. Ho nkuoa hammoho le bopaki bo fetileng ho D2-receptor binding le boits'oaro ba sechaba, karolo ea dopaminergic neurotransmission ho taolo ea lipontšo tsa taolo ea boitšoaro bo tlase le ho ikokobelletsa boitšoaro e khothalletsoa.
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