Molecular Psychiatry (2019)
inahaneloang
Serotonin le dopamine li kenella haholo ho etiology le kalafong ea mathata a ho tšoenyeha, empa lithuto tsa positron emission tomography (PET) tse batlang li-neurotransmitter tse peli tse tšoanang li haella. Morero oa thuto ena ea PET ea multitracer e ne e le ho lekola polelo ea tikoloho le tšebeliso ea liprotheine tsa transporter tsa serotonin (SERT) le dopamine (DAT) ho bakuli ba nang le khatello ea maikutlo ea sechaba. Mekhoa e tlamang e bohlale ea Voxel (BPND) bakeng sa SERT le DAT li ne li behiloe ho bakuli ba 27 ba nang le SAD le lilemo tse 43- le li-control tse tsamaeang le thobalano tse lumellanang le thobalano, ba sebelisa li-radioligands [11C] DASB (3-amino-4- (2-dimethylaminomethylphenylsulfanyl) -benzonitrile) le [11C] PE2I (N- (3-iodopro-2E-enyl) -2beta-carbomethoxy-3beta- (4'-methylphenyl) nortropane. Liphetho li bonts'itse hore, ka har'a li-transmitter, bakuli ba SAD ba bonts'itse tšebetso e phahameng ea SERT e kenyelletsang bokong ba nyutlelie ha ho fumaneha hoa DAT ho amygdala, hippocampus, le putamen ho lumellana hantle le matšoao a tebileng. Ha a le mothating oa lipalo tse ikemiselitseng, SERT le DAT BPND e ne e boetse e phahame libakeng tse ling tsa methapo le maoto le matsoho ho bakuli, hape e amana le matšoao a tebileng, athe ha ho sebaka sa boko se bontšitseng tlamo e matla taolong ea bophelo bo botle. Ho feta moo, tšebelisano-'moho ea SERT / DAT e ne e phahame haholo ho bakuli ba SAD ho amygdala, li-nucleus accumbens, caudate, putamen, le posterior ventral thalamus, ha tšebelisano-'mele e ne e bonoa ho dorsomedial thalamus. Tlhahlobo ea morao-rao ea tsamaiso ea ho latela thepa e tiisitse hore tlhahlobo ea SAD e boletsoe esale pele haholo ka tšebelisano ea lipalo pakeng tsa ho fumaneha ha SERT le DAT, ho amygdala, putamen, le dorsomedial thalamus. Ka hona, SAD e ne e amahanngoa le polelo e eketsehileng e atolositsoeng le polelo e kopaneng ea ba tsamaisang bakeng sa serotonin le dopamine maemong a ts'abo le a amanang le moputso. Mathata a amanang le "monoamine" a ka fokotsang matšoao a SAD 'me a theha sepheo sa kalafo.
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