J Neurol Sci. 2011 Nov 15; 310 (1-2): 53-7. Epub 2011 Jul 23.
Moriyama TS, Felicio AC, Chagas MH, Tardelli VS, Ferraz HB, Tumas V, Amaro-Junior E, Andrade LA, Crippa JA, Bressan RA.
mohloli o moholo
Instituto do Cérebro, Instituto de Ensino e Pesquisa do Hospital Israelita Albert Einstein, Sao Paulo, Brazil. [imeile e sirelelitsoe]
inahaneloang
Matšoenyeho a Bophelo ba Batho ba Bangata (SAD) a atile haholo ho bakuli ba PD ho feta ho bongata ka kakaretso. Mokhatlo ona o ka hlalosoa ke ts'ebetso ea kelello le ts'ebeliso ea kelello empa ho ka etsahala hape hore mochine oa neurobiological o thehiloeng ho PD o ka rera esale pele ho SAD. Morero oa thuto ena e ne e le ho etsa lipatlisiso mochine o etsahalang oa dopaminergic o amehang ho bakuli ba PD ba nang le SAD, ka ho kopanya striatal dopamine transporter binding binding (DAT-BP) ka matla a matšoao a matšoenyeho a sechaba ho bakuli ba PD o sebelisa SPECT ka TRODAT-1 joalo ka radiopharmaceutical.
Bakuli ba leshome le motso o mong ba nang le bakuli ba SAD le 21 PD ntle le SAD ba kenyelelitsoe thutong ena; lihlopha li ne li tsamaisana le lilemo, bong, nako ea mafu le ho teba ha mafu. Ts'oaetso ea SAD e ile ea khethoa ho latela maemo a DSM IV a hlahlojoang le SCID-I le matšoao a ho tšoenyeha ka sechaba sechabeng ka Brief Social Phobia Scale (BSPS). Lintlha tsa sechaba le tsa bongaka li ile tsa bokelloa. DAT-BP e ile ea hokahanngoa haholo le lintlha ho BSPS bakeng sa putamen e nepahetseng (r = 0.37, p = 0.04), putamen (r = 0.43, p = 0.02) le laudate ea morao (r = 0.39, p = 0.03). Ha ho khokahano ea bohlokoa e fumanoeng bakeng sa caudate e nepahetseng (r = 0.23, p = 0.21).
Ho fumana hona ho ka tiisa mohopolo oa hore dopaminergic dysfunction e ka kenella ho pathogeneis ea matšoenyeho a sechaba ho PD.
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