Phoso e ka fokolang ea Dopamine ea D2 ea ho amohela likhahantsoane ka Sechaba Phobia (2000)

Maikutlo a YBOP: Maemo a tlase a li-receptor tsa dopamine (D2) a amahanngoa le lefu la khatello ea maikutlo sechabeng. Batho ba bangata ba sebelisang litšoantšo tse litšila tse tsosang takatso ba ba le matšoenyeho sechabeng. Ba bang ba tlaleha keketseho ea matšoenyeho a sechaba ka mor'a ho itlopa joala. Bakeng sa boholo ba matšoenyeho a ntlafala kamora ho ithiba - bakeng sa ba bang nako e khuts'oane, ba bang nako e teletsana. Hopola hore tšusumetso e fetelletseng (litlamorao) e lebisa ho thehoeng ha li-receptor tsa dopamine D2. Tlhokomeliso: Ha ke re litšoantšo tsa bootsoa li baka maemo ohle a SAD.


2000 Mar;157(3):457-9.

Schneier FR, Liebowitz MR, Abi-Dargham A, Zea-Ponce Y, Lin SH, Laruelle M. Anxcare Disways Clinic le Brain Imaging Division, New York State Psychiatric Institute, New York 10032, USA.

SEBAKA: Phuputso ena e bapisitse dopamine D (2) receptor e tlamang bakuli ba nang le phobia ea sechaba le lithuto tse phetseng hantle.

MOTHO: Dopamine D (2) bokhoni ba ho amohela li-receptor bo ile ba hlahlojoa lithutong tse sa ngolisoang tsa 10 ka phobia e akaretsang ea sechaba mme ha ho lintlha tsa bohlokoa tsa bophelo ba kelello tsa kelello le lihlooho tsa 10 tse bapisoang hantle tsa lilemo le thobalano. Bokaholimo ba bokhoni bo ile ba lekanngoa ka har'a striatum ka ho sebelisa single photon emission computerized tomography le infusion ea kamehla ea D (2) receptor radiotracer [(123) I] iodobenzamide ([(123) I] IBZM).

LIKOTSO: Li-receptor tse bolelang tsa D (2) li ne li le tlase haholo lithutong tse nang le phobia ea sechaba ho feta lithutong tsa papiso. Ka har'a sehlopha sa phobia ea sechaba, ho ne ho e-na le ho ikamahanya ka mokhoa o sa hlonepheng oa menyetla e tlamang ka sekhahla sa Liebowitz Social Anxcare Scale.

CONCLUSIONS: Phobia e akaretsang ea sechaba e ka amahanngoa le tlamo e tlase ea [(123) I] IBZM ho D (2) receptors ho striatum.

Intro

Tlatsetso e akaretsang ea phobia ea sechaba, e khetholloang ka tšabo le / kapa ho qoba maemo a mangata a sechaba, e sa foleng (1), e-ea amoheloa (2), hape e ka arolelana likarolo tsa boits'oaro le boemo bo tlase sechabeng liphoofolong (3), empa biology ea phobia ea sechaba e sa ithutoe hanyane. Bopaki ba mokhatlo oa phobia ea sechaba le phetisetso e sa tloaelehang tsamaisong ea dopamine e kenyelletsa katleho ea kalafo bakeng sa li-inhibitors tsa monoamine oxidase empa eseng li-antidepressants (4), letsoalo le tlase la dopamine transporter ho phobia e akaretsang ea bophelo (5), maemo a tlase a CSF a homovanillic acid har'a bakuli ba ts'oenyehileng ba nang le ts'ebetso ea comorbid social phobia (6), sekhahla se phahameng sa phobia ea sechaba har'a bakuli ba nang le lefu la Parkinson (7), le matšoao a phobia ea sechaba sechabeng nakong ea kalafo ea haloperidol ea bakuli ba nang le lefu la Tourette (8).

Thutong ena re bapisitse dopamine D2 li-receptor tse tlamang bakuli ba nang le phobia e akaretsang ea bophelo le lithuto tse hlakileng tsa papiso.

METHODA

Lithuto tse leshome tse nang le phobia ea sechaba li hapiloe ke papatso le phetisetso ea bongaka; lilemo tsa bona tse mpe e ne e le lilemo tsa 32.5 (SD = 10.4), 'me sehlopha seo e ne e le banna ba bahlano le basali ba bahlano. Lithuto tsohle li ne li phetse hantle 'meleng joalokaha li hlalositsoe ke tlhahlobo ea bongaka e felletseng, ho se na psychosis ea hona joale kapa ea bophelo bo botle, khatello ea maikutlo, khatello ea maikutlo ea ho ferekana, pherekano, khatello ea kelello le khatello ea kelello, bokuli ba khatello ea maikutlo ka mora ts'ebeliso ea kelello, bothata ba ho ja, ho senyeha hoa kelello. tlhekefetso kapa ho its'epa, schizotypal kapa moeli oa botho ba leloko, kapa nalane ea lelapa ea schizophrenia. Lithuto tse leshome tse bapisang bophelo bo botle, tse amanang le lilemo le thobalano ebile li se na mathata a kelello a fetileng kapa a fetileng, li ile tsa haptjoa ke papatso. Lits'oaetso li netefalitsoe ke ho sebelisa lipotso tse hlophisitsoeng tsa Clinical Clinical for DSM-IV Axis I Disrupt (9).

Lithuto tsohle li ne li se li se na moriana oa psychotropic bonyane selemo, 'me ho ile ha etsoa skrini sa lithethefatsi pele ho hlahlojoa. Kamora ho hlalosoa ka botlalo ho thuto ho lithuto, ho fumanoe tumello e ngotsoeng e fumanoeng.

Sekala sa ho Tšoenyeha ka Sechaba sa Liebowitz (10) e ne e sebelisetsoa ho lekola botebo ba phobia ea sechaba. D2 receptor e tlamang e ka lekanngoang ka ho sebelisa radiotracer [123I] iodobenzamide ([123I] IBZM) e nang le "single Photon emission" e sebelisoang ka komporo (11). Ho ile ha sebelisoa profil e tloaelehileng ea sebaka se khahlang sa boholo le sebopeho ho lekola lithuto. Libaka tse haufi le tse ka letsohong le letšehali tsa litereke le libaka tsa maiketsetso li ne li behiloe litšoantšong tse khutsufalitsoeng. Ho tlamahanya ho khethehileng ho ile ha baloa e le phapano lipakeng tsa ts'ebetso ea boiketsetso le tšebetso ea boloi ka ho lekana. [123I] IBZM e nang le bokhoni ba ho tlama (ka ml / g), e tsamaellanang le sehlahisoa sa letsoele la mahala receptor (B, max, ho nM kapa picomoles ka gram ea lithane tsa boko) le tumellano (1 / KD, ho 1 / nM kapa milliliters a plasma ka picomole ea [123I] IBZM), e baliloe e le karo-karolelano ea ho ts'oaroa ka nako e itseng (ka li-microconomy ka gram ea lithane tsa boko) ho ea maemong a tsitsitseng a mahala a "nonmetabolised plasma tracer" (ka li-millciter ka mililita ea plasma) (12).

Sehlopha se bapisisang se sebelisitse liteko tse sa lefelloeng ka thata tsa marang-rang ka alpha ea 0.05. Ho kopanya ho ka bang teng ho ne ho amana le botebo ba tleliniki ka ya data e fetotsoeng maemo.

LIPOTSO

Ho ne ho se na phapang ea bohlokoa ea sehlopha ka lilemo, thobalano, morabe, thuto, boemo ba lenyalo kapa ho beoa.

Ho bile le phapang ea bohlokoa ho [123I] IBZM e nang le bokhoni pakeng tsa lihlopha (t = 2.6, df = 18, p = 0.02), e nang le menyetla e tlamang ho bakuli ba nang le phobia e akaretsang ea sechaba (bolela = 93.6 ml / g, SD = 29.8) ho feta lithutong tsa papiso ( bolela = 133.5 ml / g, SD = 38.2) (F1). Ka har'a sehlopha sa phobia ea sechaba, ho ne ho e-na le ho se leka-lekane ho sa kopaneng hoa bokhoni ba ho itlama ka lintlha tse felletseng ho Liebowitz Social Anxiety Scale (rs= –0.59, N = 10, p = 0.07).

TŠOHLOA

Liphumano tsena li fana ka maikutlo a hore phobia e akaretsang ea bophelo e ka amahanngoa le tlase D2 receptor e tlamang e ka khonehang ho striatum. Low D2 li-receptor tse tlamang li ka lumellana le liphetho tsa ts'ebetso ea dopamine e tlase ho phobia ea sechaba.

Boithuto bona bo lekanyelitsoe ke palo e nyane ea lithuto. Hape, hobane ke tlhahlobo e le 'ngoe feela e ikhethang e ileng ea etsoa ka thuto e' ngoe le e 'ngoe, D2 letsoalo la receptor le kamano li ne li ke ke tsa lekanngoa.

Liphumano li bonahala li ts'oana le lithuto tsa liphoofolo tsa boemo bo tlase sechabeng, bo khothalelitsoeng ho arolelana likarolo tsa boitšoaro le phobia ea sechaba sa batho (3). Mohlala, phuputso ea morao-rao ea positron emission tomography ea litšoene tsa cynomolgus tsa basali (13) e bonts'itse striatal D2 tlamahane ka tlas'a ba ka tlasa, joalo ka ha re fumana ho phobia e akaretsang ea bophelo. Liphoofolo tsa boemo bo tlase sechabeng e ka ba mohlala o thusang bakeng sa ho utloisisa tšebetso ea boko bo ka tlas'a phobia ea sechaba.

Low D2 receptor binding e bonahala e batla e batla e batla e mabapi le phobia ea sechaba, ho fapana le ho emela sets'oants'o se senang kelello sa khatello ea maikutlo kapa khatello ea kelello. D2 binding ha e so fumanoe e le tlase ho schizophrenia (14) kapa khatello e kholo ea maikutlo (15). Ho tlalehiloe hore e tlase maemong a tlhekefetso ea lithethefatsi (16), eo hangata e ka bapisoang le phobia ea sechaba (17).

Lintlha tsena li fana ka maikutlo a hore tlaase D2 li-receptor tse tlamang li ka tsamaisoa le phobia ea sechaba. Ha li kopantsoe le liphetho tse tsoang litsing tse ling, lintlha tsena li kenyelletsa bopaki bo ntseng bo hola ba hore D2 mosebetsi oa li-receptor o etsisa boitšoaro ba batho ho batho.

E amohetse Feb. 23, 1999; Lintlafatso li amohetse Julayi 13 le Aug. 27, 1999; e amohetsoe Sept. 2, 1999. Ho tsoa Tleliniking ea Matšoenyeho a ho Tšoenyeha le Karolo ea Kelello ea Brain, New York State Psychiatric Institute; le Lefapha la Psychiatry, College University College of Wagi le Baitseki, New York. Ha ho na liphatlalatso tse fumanehang. Lengolo le fumanehang ho Dr. Schneier, Anxcare Disways Clinic, Yuniti ea 69, Setsi sa Psychiatric sa New York, 1051 Riverside Dr., New York, NY 10032; [imeile e sirelelitsoe] (imeile). E tšehelitsoe ke lithuso ho tsoa ho Sycamore Foundation le ho Solvay Pharmaceuticals le NIMH Independent Scientist Award MH-01603 ho Dr. Laruelle. Bangoli ba leboha Kathy Rivera, Tami Edward, Janine Rodenhiser, Ph.D., Suehee Chung, Mali Pratap, Ted Pozniakoff, Richard Weiss, Dan Schneider, le Analea Arevalo bakeng sa thuso ea tekheniki.

TLHAHLISO 1.

Dopamine D2 Receptor Ho kopanya ho ka ba teng ho bakuli ba nang le kakaretso ea Phobia ea Sechaba le Liphetoho tsa bophelo bo botle

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