Rev Bras Psiquiatr. 2007 Mar; 29 (1): 89-90.
Corchs F, Bernik M.
Fana ka maikutlo ho - Dopamine le khatello ea maikutlo ea sechaba. [Moruti Bras Psiquiatr. 2006]
Mohlophisi ea Ratehang,
Karolo ea li-neurotransmitters ntle le serotonin mathateng a thibelo ea phobic e hlakisitsoe ha saense ea neural e ntse e tsoela pele.1 Har'a tsona, dopamine, ka kotloloho le ka litšebelisano tsa eona le lits'ebetso tse ling, ke moemeli ea hloahloa oa lipatlisiso. Tumellanong le khopolo-taba ea mongoli le tsona ke likonteraka tsa bohlokoa tsa tlhabollo ea phobias le ho haelloa ke tšusumetso e susumetsang, le ho ts'oana ho ts'oanang lipakeng tsa lefu la khatello ea maikutlo sechabeng (SAnD) le lithuto tsa litšoene tse maemong a tlase.
Ho na le sekhahla se seng mabapi le karolo ea dopamine ho SAnD le mathata a ho tšoenyeha ka ho felletseng. Hypothesis e joalo e thehiloe khopolong ea ho tšoenyeha e le boemo boo ho bona ho nang le likhohlano pakeng tsa boits'oaro bo khothalletsang / bo tiisitsoeng hantle, bo amanang haufi le litsamaiso tsa dopaminergic,2 le pholoha / Boitšoaro bo qobellang, bo amanang le litsamaiso tsa serotonergic.3
Bangoli ba bang ba se ba ntse ba shebile bohlokoa ba litsamaiso tsena tse peli ka matšoenyeho, ba hlalosa likhohlano lipakeng tsa mokhoa oa boits'oaro ba mekhoa le mokhoa oa ntoa / sefofane / freeze.4 Ka tsela ena, e tla ba ho utloahala ho nahana hore le ha lithethefatsi tsa serotonergic li ka thibela ntoa e sa tsoa hlaha kapa likarabo tsa sefofane ho beha kotsi e kholo ka ts'ebetso ea eona litabeng tsa bohlohlo tsa dorsal periaqueductal,3 ha lithethefatsi tsa dopaminergic li ka eketsa boitšoaro bo khothalletsang / takatso ea lijo ka liketso tsa eona tsamaisong ea mesolimbic,2 augmenting kahoo litlamorao tsa lithethefatsi tsa serotonergic.
Ha ho bonahale eka DA e ka ba le thepa ea "anxiolitic" ka bo eona. Lithethefatsi tse matlafatsang bioavailability ea dopaminergic, joalo ka bupropion, li na le litlamorao tse nyane kapa tse sa lumellaneng mathateng a khatello ea maikutlo. Ka lehlakoreng le leng, DA e ekelitsoeng e ka ba le tšusumetso karabong ea kalafo.
Sehlopheng sa rona, re fumane kamano e haufi ea Cloninger5 Tekanyetso ea boits'oaro le boits'oaro bo latelang kalafo ea boits'oaro ho SAnD. Tšobotsi ena e ka hokahana le ts'ebetso ea DA mme e amanang le likarabo tse ntle tsa kalafo.
Felipe Corchs, Márcio Bernik
Tleliniki ea Matšoenyeho, Setsi le Lefapha la Psychiki,
Sekolo sa Bongaka, Universidade de São Paulo (USP),
São Paulo (SP), Brazil
References
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2. RA ea bohlale. Dopamine, ho ithuta le tšusumetso. Nat Rev Neurosci. 2004; 5: 483-94.
3. Deakin JF, Graeff FG. 5-HT le mochini oa ts'ireletso. J Psychopharmacol. 1991; 5: 305-15.
4. Gray JA, McNaughton N. The neuropsychology ea matšoenyeho: ho botsa ka mesebetsi ea septo-hippocampal system. 2nd ed. Oxford: Oxford University Press; 2000.
5. Cloninger CR, Svrakic DM, Przybeck TR. Mohlala oa maikutlo le semelo sa kelello. Arch Gen Psychiatry. 1993;50(12):975-90.
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