Clozapine e na le litlamorao tse boima, empa e nkuoa e le mohanyetsi oa dopamine.
J Clin Psychiatry. 1999 Dec; 60 (12): 819-23.
Pallanti S, Quercioli L, Rossi A, Pazzagli A.
mohloli o moholo
Istituto di Neuroscienze, Univesithi ea Sekolo sa Bongaka sa Florence, Italy. [imeile e sirelelitsoe]
inahaneloang
LITLHAHISO:
Motheo oa neurochemical oa phobia ea sechaba ha o e-so hlalosoe ka botlalo, empa ho na le litlhahiso tsa ho se sebetse hantle ha serotonergic le dopaminergic dysfunction. Atypical neuroleptic clozapine ho tlalehiloe hore e baka matšoao a ho tšoenyeha, mohlomong ka lebaka la phello ea eona litseleng tsa serotonergic. Re tlaleha linyeoe tsa 12 tsa bakuli ba schizophrenic ba tsoetseng phobia ea sechaba nakong ea kalafo ea clozapine.
METHODO:
Bakuli ba ile ba hlahlojoa ba sebelisa lipotso tse hlophisitsoeng tsa Clinical Clinical bakeng sa DSM-III-R, Patient Version, Scale bakeng sa Tlhahlobo ea Matšoao a Hloekileng, Sekala sa Tlhahlobo ea Matšoao a Nepahetseng, sekala sa Liebowitz Social Phobia, le Scale Psychiatric Rating Scale. Li ile tsa ntlafatsoa bocha kamora libeke tsa 12 tsa ho phekoloa ka koazapine le fluoxetine.
LIKOTSO:
Liketsahalong tse 8 ho tse 12, matšoao a arabetse (> kapa = 35% phokotso ea lintlha tsa Liebowitz Social Phobia Scale) ka taolo ea fluoxetine.
QETELLO:
Lintlha li tšohloa ka leseli la methapo ea methapo ea kutlo le litloaelo tsa kelello tse ka hlalosang ho qaleha ha mathata a ho shebahala ka matšoenyeho (joalo ka phobia ea setjhaba) lithutong tse tšoeroeng ke thuto ea schzophrenic nakong ea tšoarelo ea matšoao a kelello.
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