Resp Psychiatry. 1999 Apr 26;90(2):91-101.
Klimke A1, Larisch R, Janz A, Vosberg H, Müller-Gärtner HW, Gaebel W.
inahaneloang
Bakuli ba leshome le metso e mehlano ba phethahatsang litekanyetso tsa DSM-IV tsa khatello e kholo ea maikutlo ba ile ba hlahlojoa le dopamine D2 receptor antagonist [123I] iodobenzamide (IBZM). Litlhahlobo tse peli tse le 'ngoe tsa photon emissions computed tomography (SPECT) li ile tsa etsoa pele le kamora libeke tsa 6 tsa kalafo ka khetho ea serotonin re-uptake inhibitor (SSRI) e khethiloeng. Striatal D2 binding receptor e ne e lekantsoe mme e lekantsoe ka mokhoa o tloaelehileng ho cerebellum. Sehlopheng sa taolo e se nang mafu a kelello (n = 17), e neng e fuputsoe hang ka [123I] IBZM le SPECT, IBZM e tlamang e fokotsehile haholo ka lilemo (0.092 ka lilemo tse leshome le motso o mong).
Tlhabollo e itšetlehileng ka lilemo e ne e le tlase maemong a nang le khatello ea maikutlo e kholo mme ha e fihle ka bohlokoa ba lipalo. Ho ne ho se na phapang ea bohlokoa molemong oa hore IBZM e tlama pakeng tsa khatello ea maikutlo le lithuto tse laoloang. Lekhalo le hlophisitsoeng la lilemo-IBZM le tlamang striatum le ne le le tlase haholo ho batho ba arabelang kalafo ho feta ho ba sa arabeng le bafo ba tepelletseng.
Ntle le moo, sehlopheng sa khatello ea maikutlo ho ne ho e-na le khokahano ea mela e pakeng tsa karabelo ea kalafo le phetoho ea li-receptor tsa D2 e tlamang nakong ea kalafo gangal. IBZM e tlamang e eketsehile ho ba arabelang kalafo mme ea fokotseha ho ba sa arabeng. Tumellanong le lithuto tsa liphoofolo, liphetho li fana ka maikutlo a kamano lipakeng tsa liphetoho tsamaisong ea dopaminergic le karabelo ea kalafo khatello e kholo ea maikutlo.
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