Psychopharmacology (Berl). 2018 Aug 22. doi: 10.1007 / s00213-018-5007-4.
Lamontagne SJ1, Melendez SI1, Olmstead MC2,3.
inahaneloang
RATIONALE:
Anhedonia, e haellang ts'ebetsong ea meputso, ke mofuta oa maemo a mangata a amanang le neuropsychiatric. Leha e atile ebile e na le litlamorao tse fokolisang, kalafo ea anhedonia e haelloa, haholoholo hobane ts'ebetso ea eona e sa utloisiseng hantle. Dopamine (DA) e kentse letsoho ho anhedonia ka karolo ea eona lithutong tse amanang le moputso; Lisistimi tsa glucocorticoid le tsona li ka ameha ka hore hangata anhedonia e tla pele ho khatello ea maikutlo e sa foleng.
MORERO:
Boithuto bona bo fuputse tšebetso ea DA le glucocorticoid ho anhedonia ba sebelisa mofuta oa rat oa mosebetsi oa moputso oa probabilistic (PRT).
LITLHAHISO:
Liroto tsa banna ba baholo tsa Wistar li ile tsa koetlisetsoa PRT 'me tsa hlahlojoa ho latela: (1) activation kapa inhibition ea tšebetso ea DA e hlahisoang ke lijoala tsa amphetamine (AMPH) kapa pramipexole (PRAMI), (2) khatello e bonolo ea khatello ea maikutlo (CMS), kapa (3) glucocorticoid system activation (dexamethasone (DEX)) kapa inhibition (mifepristone (MIFE)).
LIKOTSO:
AMPH e ile ea eketseha mme PRAMI e fokotsa leeme la karabelo, e supa ho ntlafatsa le ho fokotsa karabelo ea moputso ka agonism ea DA le ho hanyetsa, ka ho latellana. CMS e fokotsitse ho hloka leeme empa e le feela ho hokahaneng ha likhoto. DEX e boetse e thelositse karabelo, e fana ka tlhahiso ea hore lits'ebetso tsa glucocorticoid li kenya letsoho ho anhedonia, le ha glucocorticoid inhibition (MIFE) e se na phello. Ha ho le e 'ngoe e fetotseng bokhoni e fetotseng bokhoni ba ho bona le ho nka bohato ka tšusumetso e etsoang ka moputso.
CONCLUSIONS:
Liphetho tsena li tiisa karolo ea DA ho anhedonia mme e hlakisa tlatsetso ea sistimi ea glucocorticoid ho sena. Ntle le moo, khatello ea maikutlo e sa foleng e ka kena-kenana le tšebetso e tloaelehileng ea DA, ea lebisa ho thuto e sa sebetseng e amanang le moputso liphoofolong tse ling. Liphumano tsena li ka lebisa kalafo ea kamoso ea anhedonia ka ho shebisa litsamaiso tsa DA le glucocorticoid, hammoho le tšebelisano e ka bang teng lipakeng tsa bobeli.
LINKOTSO: CMS; Ho sithabela maikutlo; MDD; Moputso; Khatello ea maikutlo
PMID: 30136143
DOI: 10.1007/s00213-018-5007-4
;
