Bafuputsi ba fumane hore lithethefatsi tse loantšang khatello ea maikutlo joalo ka Prozac ha li ame feela maemo a serotonin ea methapo ea kutlo bokong, empa hape le "ho koetela" pontšo ea dopamine hape e e bakang hore e hlahise matšoao a serotonin. Liphuputso tsa bona li fana ka leseli le lecha mabapi le hore na Prozac le tse ling tse "khethollang serotonin uptake inhibitors" (SSRIs) li sebetsa joang le hore na li ka baka mathata joang ho bakuli ba li noang.
Li-SSRIs li etsa mosebetsi oa tsona oa ho fokotsa khatello ea kelello ka ho eketsa khatello ea serotonin manonong a saeneng a bitsoang li-synapses, lipakeng tsa methapo ea kutlo. Keketseho ena e fokotsa khaello ea serotonin e bakang khatello ea maikutlo.
Joalokaha lebitso la bona le bonts'a, li-SSRIs li thibela ho nka serotonin kamora hore e phethe mosebetsi oa eona e le len messengerosa la lik'hemik'hale le thusang neuron e le 'ngoe ho baka tšusumetso ea methapo ho moahisani. Li-SSRIs li thibela ts'ebeliso ena ka ho thibela ts'ebetso ea bakuli ba ratoang ba limolek'hule tse bitsoang baetsi ba phetisetso ea serotonin ho khutlisetsa litsing tsa polokelo tsa methapo tse bitsoang vesicles.
Joale, leha ho le joalo, Fu-Ming Zhou (hajoale ke Univesithi ea Tennessee) le basebetsi-'moho le eena Baylor College of Medicine ba senotse hore li-SSRI li ka ba le litlamorao tse rarahaneng haholo sephethephethe sa methapo ea kutlo bokong ho feta feela ho fetola maemo a serotonin. Ba fumane hore lipalo tse phahameng tsa serotonin tse bakoang ke li-SSRI li ka "qhekella" ba tsamaisang sesebelisoa se seng sa bohlokoa sa methapo ea kutlo, dopamine, hore ba fumane serotonin ho li-vesicles tsa dopamine. Barekisi ba Dopamine ba na le kamano e tlase ea serotonin, empa maemo a phahameng a serotonin a fella ka hore e nkuoe ke bapalami ba dopamine, ba fumane bo-rasaense.
Ka lebaka leo, ho thunya ho tloaelehileng ho bakoang ke dopamine ho tsoa ho li-neuron tse joalo, ha e le hantle, ho hlahisa mefuta e 'meli e fapaneng ea lithunya tsa neuronal, e bakang "cosignaling."
Bafuputsi ba ile ba tataisoa ho ithuta karolo ea ho supa dopamine ts'ebetsong ea SSRI ke bopaki ba pejana ba hore dopamine e ne e kenyelletsa khatello ea maikutlo le ts'ebetsong ea lingoloa tsa khatello ea kelello bokong. Ba ithutile sebopeho sa mochine oa serotonin le dopamine ka ho phekola lisosa tsa boko ba mouse ka fluoxetine (Prozac) le lik'hemik'hale tse ling, le ho hlahloba litlamorao ho mochine oa dopamine-signaling.
Mokhoa o batlang o sa sebetse, o liehang oa "ho koetela" ba tsamaisang dopamine ka serotonin nakong ea kalafo ea SSRI e ka hlalosa hore na hobaneng ho nka matsatsi a mangata a kalafo pele litlamorao tsa khatello ea maikutlo li bonoa, bafuputsi ba khothalelitse.
Ba boetse ba ngotse hore liphuputso tsa bona li kanna tsa hlalosa hore na hobaneng kalafo ea bana ba nang le fluoxetine e ka baka matšoao a nyahamisang ha e se e le motho e moholo. Bafuputsi ba ngotse hore, kaha serotonin e bapala karolo ea bohlokoa ho nts'etsopele ea neuronal, ho sitisoa ke fluoxetine ea maemo a tloaelehileng a serotonin nakong ea kholo e ka ikarabella bakeng sa tlhekefetso e joalo ea boits'oaro.
Ba boetse ba re khopolo ea mantlha ea dopamine le serotonin e bakoang ke li-SSRI e ka hlalosa linyeoe tsa "lefu le ka 'nang la beha bophelo" serotonin syndrome "le bakoang ke maemo a kang ho ja lijo tse ngata tsa pele ho serotonin ho batho ba nkang SSRIs.
Bafuputsi ba ngotse hore kamano lipakeng tsa dopamine le lets'oao la serotonin "e kanna ea hlokahala bakeng sa boits'oaro bo tloaelehileng le bakeng sa mafu a ka alafshoang ka li-SSRI." Karolo ea boko e amehang, ventral striatum, "e amehile haholo ts'ebetsong ea methapo ea kutlo le moputso." Ka hona, ba ngotse, ho nka karolo ho matlafalitsoeng ha sisteme ea striatal dopamine ho saeneng serotonin nakong ea kalafo le li-SSRI "ho ka kenya letsoho katlehong ea kalafo ea li-SSRI."
Fu-Ming Zhou, Yong Liang, Ramiro Salas, Lifen Zhang, Mariella De Biasi, le John A. Dani: "Corelease ea Dopamine le Serotonin ba tsoang Striatal Dopamine Terminal"
Ho phatlalatsa ho Neuron, Moqolo 46, Nomoro ea 1, April 7, 2005, maqephe 65-74. http://www.neuron.org
Bafuputsi ba kenyelletsa Fu-Ming Zhou oa Baylor College of Medicine (hona joale Univesithing ea Tennessee) le Yong Liang, Ramiro Salas, Lifen Zhang, Mariella De Biasi, le John A. Dani oa Baylor College of Medicine. Mosebetsi ona o tšehelitsoe ke National Institute on Drug Abuse, National Institute of Neurological Disorders and Stroke, le lithuso tse tsoang ho National Alliance for Research on Schizophrenia and Depression (FMZ) le tse tsoang ho National Institutes of Health. John A. Dani o kopa 'moho le li-Bioscience tsa Silico ho ts'ehetsa ho sibolla le ho hlahloba lithethefatsi.
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