J Neurosci. 2017 Aug 8. pii: 1181-17. Doi: 10.1523 / JNEUROSCI.1181-17.2017.
Weixin Z1,2, Li Y2,3, Feng Q2,3, Luo M4,2,3.
inahaneloang
Bokhoni ba ho bolela moputso bo etsa hore liphoofolo li pholohe. Bobeli ba dopamine neurons sebakeng sa ventral tegmental (VTA) le li-neuron tsa serotonin sebakeng sa dorsal raphe nucleus (DRN) ba nka karolo ho etseng moputso. Le ha litlamorao tsa ho ithuta ho li-neurop tsa dopamine li bontšitsoe haholo, e ntse e sa tsejoe haholo hore na karabelo ea li-neuron tsa neurot e fetoha joang nakong ea ho ithuta. Ntle le moo, le ha khatello ea maikutlo e tsebahala ho susumetsa ka matla boits'oaro bo amanang le moputso, ha re tsebe letho ka hore na khatello ea maikutlo e fetola likarabo tsa moputso oa neuronal joang. Ka ho beha leihlo Ca2+ lipontšo nakong ea ts'ebetso eohle ea boemo ba Pavlovian, mona re bonts'a hore ho ithuta ho fapana ka sebopeho sa sebopeho sa likarabo tsa methapo ea methapo ea kutlo le li-dopamine neurons litoeba tsa bong kapa bofe. Li-neuron tsa Serotonin butle-butle li theha karabelo e liehang ho moputso, 'me qetellong li lula li amohela moputso, athe li-neurop tsa dopamine li eketsa karabelo ea tsona ho cue empa li fokotsa karabelo ea tsona moputsong. Bakeng sa mefuta ka bobeli ea neuron, likarabo ho cue le moputso li latela boleng ba moputso, lia khutlisoa ha moputso o sa tloheloa, 'me li khutlisoa ka potlako ka ho khutlisa moputso. Re fumane hape hore likhatello tse kenyelletsang ho thijoa ke hlooho le maemo a tšosang haholo li fokotsa matla a karabelo a mefuta ka bobeli ea neuron, ho ea ho cue le moputsong. Liphetho tsena li senola ts'ebetso e kholo ea likarabo tsa moputso, li ts'ehetsa maikutlo a hore li-neurons tsa DRN li supa monyetla oa ho fumana melemo, 'me li fana ka maikutlo a hore phello ea khatello ea maikutlo ho likarabo tsa moputso tsa li-neurot tsa serotonin le li-neuron tsa dopamine li ka tlatsetsa khatellong. anhedonia.
Polelo ea Bohlokoa
Ka bobeli li-neurot tsa serotonin tse sebakeng sa dorsal raphe le li-neurop tsa dopamine tse sebakeng sa ventral tegmental li kenella ka botebo ts'ebetsong ea moputso. Ho sebelisa liforomo tsa nako e telele tsa fiber2+ matšoao a tsoang litoeba tsa boits'oaro bo lokolohileng, re bonts'a hore ho ithuta ho hlahisa mokhoa o potlakileng oa ts'ebetso ho li-neuron tsa seroton tse fapaneng le tseo ho li-neurop tsa dopamine, ho bonts'a likarolo tse tlatsetsang tsa mefuta ena e 'meli ea li-neuron ts'ebetsong ea moputso. Ho feta moo, kalafo ea khatello ea maikutlo e fokolitse haholo karabelo ea moputso oa li-neuron tsa serotonin le tsa dopamine, e fana ka maikutlo a hore ho ka ba le motheo oa 'mele bakeng sa anhedonia e bakang khatello ea maikutlo.
PMID: 28821671
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