Nucleus Accumbens Medium Spiny Neuron Subtypes Liphello Tse Amanang le ho Tepella Maikutlong-Liphello Tse Amanang le ho Hlōla Khatello ea Sechaba (2014)

Biol Psychiatry. 2014 Jul 28. pii: S0006-3223 (14) 00554-X. Doi: 10.1016 / j.biopsych.2014.07.021.

Francis TC1, Chandra R1, Motsoalle DM2, Finkel E1, Dayrit G3, Miranda J4, Brooks JM1, Iñiguez SD5, O'Donnell P.1, Kravitz A2, Lobo MK6.

inahaneloang

LITLHAHISO:

Li-nucleus accumbens ke mokena-lipakeng oa khatello ea maikutlo e amanang le khatello ea maikutlo ho khatello ea maikutlo ea taolo ea sechaba. Boithuto bo fetileng bo bonts'a liphetoho tse ikhethileng tsa neuroplasticity ho li-subtypes tse peli tse mahareng tsa li-spiny neuron (MSN), tse ruisitsoeng ho dopamine receptor D1 le dopamine receptor D2, ka moputso le ts'ebeliso e lebisang ho aroleng likarolo tsa li-MSN tsena ka mekhoa ena. Leha ho le joalo, likarolo tse ikhethileng tsa li-nucleus li bokella li-subtypes tsa MSN, ka khatello ea maikutlo, li lula li sa utloisisehe hantle.

LITLHAHISO:

Re sebelisa li-cell patch clamp electrophysiology, re ile ra hlahloba ho kenella ho li-subtypes tsa MSN le mehato e makatsang ea ho thabela litheko tsa protheine tsa D1-green fluorescent le litoeba tsa D2-green fluorescent bactericial chromosome transgenic transse e nang le khatello ea maikutlo ea tlhaselo ea khatello ea sechaba (CSDS). Mekhoa ea optogenetic le ea drugacogenetic li ile tsa sebelisoa ho leka ho chencha lithunya tsa D1-MSN kapa D2-MSNs kamora CSDS kapa pele ho ts'ebeliso ea khatello ea khatello ea sechaba ho D1-Cre kapa D2-Cre bacterial chromosome transgenic mice.

LIKOTSO:

Re bonts'a hore maqhubu a phello ea thabo e kopanyang synaptic a fokotsehile ho D1-MSNs mme a eketseha ho D2-MSN ka litoeba tse bonts'ang boits'oaro bo kang bo sithabetsang maikutlo kamora CSDS. Ntlafatso ea ts'ebetso ho D1-MSNs e hlahisa sephetho sa boitšoaro bo tiileng, ha thibelo ea li-MSN tsena e etsa hore ho be le liphetho tse kang tsa khatello ea maikutlo kamora CSDS. Ho feto-fetoha ha maikutlo ha Bidirectional ea D2-MSN ha ho fetole likarabo tsa boitšoaro ho CSDS; leha ho le joalo, ts'ebetso e pheta-phetoang ea D2-MSNs literekeng tsa khatello ea kelello na indve e etsa hore ho qojoe tikoloho ho latela khatello e tlase ea khatello ea sechaba.

CONCLUSIONS:

Lithuto tsa rona li senola mesebetsi e mengata ea li-subtypes tsa MSN litlamorao tse kang khatello ea maikutlo. Haholo, phetoho ea kabelo ea mesebetsi e amanang le D1-MSN e khothalletsa sepheo se fapaneng sa boitšoaro ho khatello ea kelello ea sechaba. Ka hona, ho lebisa ts'ebetso ea D1-MSN ho ka fana ka maano a kalafo a noo bakeng sa khatello ea maikutlo kapa mathata a mang a amanang.

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