Ha mokete o felile: linaha tse kang ho tepella maikutlo likarolong tse latelang ho felisoa ha molumo oa cortic D1 ka ho feteletseng.

Psychopharmacology (Berl). 2016 Jan 14.

Freund N1,2, Thompson BS3, Sonntag K3, Meda S3, Andersen SL3.

inahaneloang

RATIONALE:

Keketseho ea ts'ebetso ea li-receptor tsa DPNUMX tsa preopal (D1R) e kenella mekhoeng e amanang le moputso e fumanoang boteng le bokhobeng ba lithethefatsi. Le ha litlamorao tsa D1R tse phahameng li tsejoa, boits'oaro bo joalo bo sithabetsang maikutlo bo hlaha le litsietsing tsena kamora ho batla meputso.

LIPOTSO:

Morero ke ho bontša hore na ho felisoa ha D1R overexpression ho susumetsa boits'oaro bo joalo ba boits'oaro.

LITLHAHISO:

Anctucible (Tet.On), lentiviral veter e ne e sebelisoa ho qhekella polelo ea mofuta oa DRD1 ka li-neuron tsa glutamate kahare ho cortex ea pele ho banna, likhoto tse kholo. Ts'ebetso ea thobalano le likhetho tsa sucrose li ithutile ho D1R e phahamisitsoe ON le litulo tse tlase tsa OFF. Kamora ho felisoa ha D1R ON mmuso, boits'oaro bo joalo bo sithabetsang bo ile ba khethoa seterekeng sa OFF. Pontšo ea "transcriptal regator", cyclic AMP-reactionful element-binding protein (CREB) e ne e sebelisoa e le sesupo sa litla-morao tsa ts'ebetso ea methapo ea methapo (NA).

LIKOTSO:

HO Pontšo ea D1R ho ekelitse thobalano e khutlelang motheong oa mantlha seterekeng sa OFF. Likhetho tsa Sucrose li eketsehile ~ 6% ho ON state empa li oele 11% ka tlasa maemo a taolo ha OFF. Tumellanong le phenotype e nyahamisang joalo ka D1R OFF e theotse ts'ebetso ka 40%, e sitisitse bokhoni ba ho laola (43%) le tšusumetso ea ho baleha ts'oaetso (27% e holofetseng ho feta) mabapi le dsRed OFF. CREB e eketsehile 29% ho NA seterekeng sa D1R OFF ha ho bapisoa le naha ea ON.

CONCLUSIONS:

Mokhoa ona oa lipale o bonts'a hore polelo e phahameng ea D1R e ile ea eketsa boitšoaro ba hedonic, athe ho felisoa ha D1R overexpression hangata ho fella ka boitšoaro bo sithabetsang. Boitlhotlhollo bona bo tšehetsa karolo ea D1R expression cycling in boitšoaro bo amanang le phallo le ho lemalla.

LINKOTSO:

Tlatsetso; Bipolar disorder; Hedonia; Lentivirus; Pele ho cortex; Rat