Biol Psychiatry. 2015 May 15; 77 (10): 903-11. Doi: 10.1016 / j.biopsych.2014.10.024. Epub 2014 Nov 13.
Saddoris MP1, Sugam JA1, GD ea Stuber2, E ngotsoe IB3, Deisseroth K4, Carelli RM5.
inahaneloang
LITLHAHISO:
Ho etsa liqeto tse nepahetseng, likokoana-hloko li tlameha ho lekanya litšenyehelo le melemo ea liphetho tsa bohlokoa tse ka bang teng, e leng mohato o tsejoang ho kenyelletsa li-nucleus accumbens (NAc) le tlhahiso ea tsona ea dopaminergic. Leha ho le joalo, hajoale ha ho tsejoe haeba dopamine e latela ka botebo liphetoho tse lebelloang molemong oa moputso ha litabatabelo tsa boitšoaro li fetoha 'me ho le joalo, haeba e hokahantsoe le likarolo tse itseng tsa boleng joalo ka phaello ea moputso le / kapa ho lieha ho tiisa.
LITLHAHISO:
Mekhoa ea Electrochemical e sebelisitsoe ho lekanya ho lokolloa ha subsecond NAc dopamine nakong ea mosebetsi oa ho liehisa moo ho tsitsitseng moo boholo bo neng bo behiloe empa ho lieha ho fapana ka lithibelo (n = 7 rats). E latelang, ho lekola hore na ho saena hoa dopamine ho ne ho amana hantle le likarolo tse ikhethileng tsa boits'oaro, re sebelisitse khetho ea optogenetic e khethiloeng ea li-terminals tsa dopamine ho NAc re sebelisa mosebetsi o fokotsoang oa ho fokotsa litšenyehelo moo boholo ba ho lieha le boholo bo neng bo fapana ka bo fapaneng (n = 23 rats).
LIKOTSO:
Ces e boletsoeng esale pele ka likhetho tse teng e entse hore ho lokolloe dopamine e neng e thehiloe le likhetho tse ratoang ke rat 'me e fetotsoe ka matla ha e lieha ho tiisa moputso o moholo. Boitekong ba bobeli, ho saena ka dopamine ho ne ho amana hantle le likarolo tsa ho nka liqeto, kaha tlhahiso ea dopamine e ntlafalitsoeng kahare ho NAc nakong ea tlhahiso ea polelo ea morao-rao e ne e lekane ho fetola likhetho tse amanang le boleng bo latelang. Habohlokoa, phetoho ena e kopantsoeng le dopamine e ne e lekanyelitsoe ho liqeto tse nkiloeng motheong, empa eseng ho latela boholo.
CONCLUSIONS:
Liphumano tsena li bonts'a hore NAc dopamine e latela ka mokhoa o hlakileng ho liehisa ho theola le ho theha karolo e ratoang ea ho tšoaea sena sethaleng sa maano a amanang le boleng.
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