Tšoaetso ea dopamine D1 le D2 sepakapaka se sebetsang ka litšoene tse nang le li-cynomolgus tsa sechaba se itšetlehileng ka cocaine (2004)

RATIONALE:

Boemo ba sechaba bo bontšitsoe hore bo susumetsa ts'ebetso ea dopamine (DA) D (2) receptor le ho ba kotsing ea ho itlhokofatsa ka koae ka litšoene tsa cynomolgus. Lithuto tse teng li ne li etselitsoe ho pharalatsa liphumano tsena molemong oa ho ntlafatsa koae ea koae le li-receptors tsa DA D (1).

MORERO:

Lekola litlamorao tsa ts'ebeliso e phahameng ea katleho ea D (1) ka boits'oaro bo sa sebetseng (ho shebella ka mahlo) le agonist e fokolang ea D (1) mabapi le ho itaola ka koae, hammoho le litlamorao tsa ho pepeseha hoa koae ho D (2) sebetsa mesebetsing ea sechaba, joalo ka ha ho laetsoe ke positron emission tomography (PET).

LITLHAHISO:

Litlamorao tsa ts'ebeliso e phahameng ea bokhoni ba D (1) SKF 81297 le cocaine (0.3-3.0 mg / kg) ho blinkingous li ile tsa tšoauoa ka litšoene tse robeli nakong ea tlhahlobo ea 15-min. Ka mor'a moo, bokhoni ba agonist SKF 1 (38393-0.1 mg / kg) ea ho fokotsa ts'ebetso ea cocaine (17-0.003 mg / kg ka sejo se seng le se seng, IV) e ile ea hlahlojoa ka litšoene tsa 0.1. Kemiso ea 11 e lekantsoeng. Qetellong, litekanyetso tsa li-receptor tsa D (50) ka har'a caudate le putamen li ile tsa hlahlojoa ho litšoene tse leshome le metso e robong tse sebelisang PET.

LIKOTSO:

SKF 81297, empa eseng koae, e eketsehile haholo litšoeneng tsohle, e na le litšoene tse kholo ho feta litšoene tse hlaheletseng. Tekanyetso ea SKF 38393-e theotsoe ka ho fokotseha litekanyetso tsa karabelo e sebelisoang ke koae ka tšebeliso e ts'oanang ea boits'oaro le katleho ho maemo ohle a sechaba. Kamora pale e pharaletseng ea ts'ebetso ea k'hok'heine, D (2) li-receptor ha lia ka tsa fapana ho latela maemo a sechaba.

CONCLUSIONS:

Liphetho tsena li bontša hore tšebetso ea li-receptor ea D (1) ha e susumetsoe haholo ke maemo a sechaba ho litšoene ho tsoa lihlopheng tse ikemetseng tsa sechaba. Le ha tlhahlobo ea pejana e bontšitse hore litšoene tse hlahelletseng li ne li na le li-receptor tse phahameng tsa D (2) mme li ne li sa amehe haholo ka litlamorao tse matlafatsang tsa koae nakong ea ho pepesoa ha mantlha, liphumano tse teng hona joale li bonts'a hore tšebeliso ea cocaine ea nako e telele e fetotse maemo a receptor a D (2) joalo ka D. (2) ts'ebetso ea li-receptor le matlafatso a koae li ne li sa fapana lipakeng tsa maemo a sechaba. Liphumano tsena li fana ka maikutlo a hore ho pepesetsoa koae ho hlahisitse tšusumetso ea matlo a boiketlo mosebetsing oa DA receptor.