Tšebelisano pakeng tsa dopamine D2 receptors ka sekhahla sa ventral le tshebetsong e kholo ea joala cues le takatso (2004)

Am J Psychiatry. 2004 Oct;161(10):1783-9.

Heinz A1, Siessmeier T, Kwang J, Hermann D, Klein S, Mohlokomeli SM, Flor H, Braus DF, Buchholz HG, Mofumahali Gründer G, Schreckenberger M, Smolka MN, Rösch F., Mann K, Bartenstein P.

Erratum ho

  • Ke J Psychiatry. 2004 Dec; 161 (12): 2344. Grüsser-Sinopoli, Sabine M [o lokiselitsoe ho Grüsser, Sabine M].

inahaneloang

MORERO:

Tai le lithethefatsi tse ling tsa tlhekefetso li khothalletsa ho lokolloa ha dopamine kahare ho "ventral striatum", e kenyelletsang li-nucleus bokella, karolo ea mantlha ea tsamaiso ea moputso oa boko, le ho tiisa ts'ebeliso ea lithethefatsi. Ho ja joala bo sa foleng ho tsamaisana le taolo e tlase ea li-receptor tsa dopamine D (2), le ho lieha ho hlaphoheloa ha sensitivity ea D (2) kamora hore detoxation e kopane hantle le kotsi e kholo ea ho khutla hape. Ho se sebetse hantle ha mokokotlo ka nako e telele (2) ha ho kenelle ka hare ho moea ho ka kena-kenana le letšoao le lemalloang la dopamine, 'me ea emisa ts'ebetso ea moputso oa boko mabapi le tšusumetso e fetelletseng ea ts'usumetso e amanang le joala.

METHODO:

Multimodal imaging, e nang le radioligand [(18) F] desmethoxyfallypride le positron emission tomography le ts'ebetso ea ts'ebetso ea matla a resonance imaging (fMRI), e ne e sebelisoa ho bapisa lino tse tahang tsa banna ba 11 detoxified le banna ba phetseng hantle ba 13. Bangoli ba lekantse mokhatlo oa D (2) o tšoanang le li-dopamine li-dopamine sethaleng se kenang kahare le takatso ea joala le ts'ebetso e bohareng ea likhoele tsa joala.

LIKOTSO:

Ts'ebetso ea "cortex" ea mori e tlang pele ho nako le ho susumetsoa ke tšusumetso e amanang le joala, e amanang le ts'usumetso e khothalletsoang ke maikutlo a sa jeleng paate, e ne e le kholo ho joala joala bo fuoang ho feta ho banna ba phetseng hantle. Makhoba a joala a bonts'itse phokotso e fokolang ea li-receptor tse kang D (2) tse fumanehang kahare ho terral striatum, e neng e amahanngoa le takatso e matla ea joala le ts'usumetso e kholo ea ts'usumetso ea cortex ea medial pele le cingrate ea ka ntle joalokaha e lekiloe le fMRI.

TŠOHLOOHO:

Ho lino tse tahang, dopaminergic dysfunction ka hare ho ventral striatum e ka hlahisa sesosa sa ts'usumetso e amanang le joala, hoo joala bo ka tsosang takatso le ts'ebetso e feteletseng ea marang-rang a neural a amanang le taolo le boitšoaro.