D1 le D2 dopamine-receptor ho feto-fetoha ha molumo oa ho hlasela ho hlaselang ha li-spin neurons (2007)

Trends Neurosci. 2007 May; 30 (5): 228-35. Epub 2007 Apr 3.

Khaled Ahmed1, Ding J, Letsatsi M, Wang Z, Shen W.

inahaneloang

Dopamine e bopa mefuta e fapaneng ea mesebetsi ea psychomotor. Sena se etsoa haholo ka ho fetolela lipontšo tsa "cortical" tsa "cortical" le "palamic glutamatergic" tse fanang ka maikutlo a mantlha a pakeng tsa li-spiny neurons (MSNs) tsa striatum.

Lintlha tse 'maloa tsa bopaki li bontša hore dopamine D1 receptor signaling e ntlafatsa thabo ea dendritic le matšoao a glutamatergic ho li-striatonigral MSNs, athe li-D2 receptor li fana ka phello e fapaneng le ea li-stNatopallidal MSNs. The antagonism e sebetsang pakeng tsa li-receptor tsena tse peli tse kholo tsa dopamine e fetela ho taolo ea polasetiki ea synaptic.

Boithuto ba morao-rao, bo sebelisa litoeba tsa transgenic tseo lisele li hlahisang li-receptor tsa D1 le D2, li sibollotseng liphapang tse sa ananeloeng lipakeng tsa li-MSN tse etsang sebopeho sa glutamatergic signaling le tšusumetso ea DA ho polasetiki ea synaptic. Lithuto tsena li boetse li bonts'itse hore liphetoho tsa nako e telele ho ho saena ha dopamine li hlahisa phetoho e tebileng le mofuta oa sele e ikhethang ea ho kopanya le ho sebetsa ha corticostriatal.