J Neurosci. 2012 Jun 27; 32 (26): 9023-9034.
Anzalone A, Lizardi-Ortiz JE, Ramos M, De Mei C, Hopf FW, Iaccarino C, Halbout B, Jacobsen J, Kinoshita C, Welter M, Caron MG, Bonci A, Sulzer D, Borrelli E
mohloli o moholo
Lefapha la Microbiology le Molekara Genetics, INSERM U904, Univesithi ea California Irvine, Irvine, California 92697, Lefapha la Psychiatry, University University, New York, New York 10032, Ernest Gallo Clinic le Setsi sa Patlisiso, Univesithi ea California, San Francisco, Emeryville, California 94608, Lefapha la Biology ea Cell, Setsi sa Bongaka sa Duke University, Durham, North Carolina 27710, Lenaneo la Patlisiso ea Intramural, Setsi sa Naha sa Ts'ebeliso e Mpe ea Lithethefatsi, Baltimore, Maryland 21224, le Mafapha a Neurology le Pharmacology, Columbia University, New York, New York 10032 .
inahaneloang
Dysfunctions tsa dopaminergic homeostasis e lebisang maemong a tlase kapa a phahameng a dopamine (DA) a hokahantsoe le lefu la Parkinson, schizophrenia le bokhoba ba tahi. Libaka tse kholo tsa tšebetso ea DA ke mesencephalic neurons e tsoang sebakeng sa substantia nigra le ventral tegmental; meaho ena e romella likhakanyo tse kholo ho dorsal striatum (DSt) le nucleus accumbens (NAcc), ka ho latellana. DA e hlophisa hantle le ho e lokolla ka ho kenya tšebetsong li-receptor tsa DA D2 (D2R). Ho fihlela joale, ts'ebetso ena ea bohlokoa e itšetlehileng ka D2R e ne e nahanoa e le feela ka lebaka la ts'ebetso ea li-D2R ho li-dopaminergic neurons (D2 autoreceptors); Sebakeng seo, re sebelisa litoeba tse ikhethileng tsa D2R tse fumanehang sebakeng sa marang-rang, re fumana hore li-heteroreceptor tsa D2 tse fumanehang ho li-neurons tse seng tsa DAergic medium spiny li nka karolo taolong ea maemo a DA. Sesebelisoa sena sa D2 heteroreceptor-mediated se sebetsa hantle ho DSt ho feta ho NAcc, ho bonts'a hore ho saenahale ha D2R ho laola mesebetsi ea mesolimbic- le ea nigrostriatal. Phuputso ena e senola taolo e neng e sa ananeloe ea ho saena ea DA, e fana ka leseli le lecha mabapi le taolo e ikhethileng ea tikoloho ea litlamorao tse kopantsoeng ke DA
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