Neuropsychopharmacology. 2015 Mar 4. Doi: 10.1038 / npp.2015.60.
de Jong JW1, Roelofs TJ1, Mol FM1, Hillen AE1, Meijboom KE1, Luijendijk MC1, van der Eerden HA1, Garner KM1, Vanderschuren LJ2, Adan RA1.
inahaneloang
Matšoao a fetohileng a mesolimbic dopamine a bile le tšusumetso e matla boits'ebetsong ba bokhoba. Boholo ba mosebetsi ona o shebile ho dopamine kahare ho striatum, empa ho na le bopaki bo hlahang bakeng sa karolo ea auto-inhibitory, somatodendritic dopamine D2 receptor (D2R) sebakeng sa ventral tegmental area (VTA) ka ts'ebelisong. Kahoo, ho fokotsoa ha polelo ea midbrain D2R ho bile le tšusumetso ho tlatsetso ho batho. Ho feta moo, ho kokota ha gene e kenyang D2R receptor (Drd2) ho dopamine neuron ho bontšitsoe ho ntlafatsa karabelo ea locomotor ho koae ka litoeba.
Ka hona, mona re lekile monahano oa hypothesis o fokotsetsang polelo ea D2R ho VTA ea likhoto tsa batho ba baholo, o sebelisa shRNA knockdown, o khothaletsa boitšoaro bo kang bokhoba ho likhoto tse arabelang kocaine kapa lijo tse fumanehang habonolo. Likhoto tse nang le VTA D2R tse fokotsehileng li bontšitse tšusumetso e matla haholo ho li-sucrose le cocaine tlasa kemiso e tsoelang pele ea matlafatso, empa ho fumana kapa ho boloka tsamaiso ea koae ka bohona ha hoa ka ha ameha.
Ba boetse ba bonts'itse ts'ebetso e ntlafalitsoeng ea koae, e ntlafalitsoeng, empa ha ho phetoho phetolelong ea basal. Keketseho ena e matla ea ts'usumetso ea ts'usumetso e ne e tobile ka boits'oaro, hobane ha re ka ra bona phapang lipakeng tsa karabelo e tsitsitseng, ho arabela ka mokhoa o feteletseng, ho khutlisetsoa kapa ho hatelloa ka mokhoa o hlakileng oa ho ts'oara koae le ho ts'oara ho batla.
Re phethela ka hore VTA D2R knockdown e hlahisa sepheo se matla sa khothalletso, empa ha e khothalletse ka kotloloho likarolo tse ling tsa boits'oaro bo joalo ba bokhoba.
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