LINTHO: Puso ea sechaba e eketsa li-receptor tsa dopamine D2 ho li-primates. Boitšoaro bo botle ba banna bo nahanoa hore bo amana le keketseho ena ea ho bontšoa dopamine. Litlokotsi li baka ho theoha hoa li-receptors tsa D2. Na melemo (ho itšepa, ho ba le setsoalle le batho ba bang, ho susumetsa, ho tšoenyeha ho fokolang) banna ba ikutloa ha ba ntse ba hlaphoheloa bokhobeng ba litšoantšo tsa bootsoa e ka amana le keketseho ea li-receptor tsa D2?
Nat Neurosci. 2002 Feb; 5 (2): 169-74.
Morgan D, Grant KA, Gage HD, Mach RH, Kaplan JR, Prioleau O, Nader SH, Buchheimer N, Ehrenkaufer RL, Nader MA.
mohloli o moholo
Lefapha la Physiology le Pharmacology, Wake Forest University School of Medicine, Setsi sa Bongaka sa Bongaka Boulevard, Winston-Salem, North North 27157, USA.
inahaneloang
Ho senyeha ha sistimi ea dopaminergic ho kentsoe letsoho ho etiology ea maemo a mangata a mafu, ho kenyeletsoa le ho lemalla lithethefatsi. Mona re ne re sebelisa setšoantšo sa positron emission tomography (PET) ho ithuta ts'ebetso ea bokong ea dopaminergic ka bolulo ka bomong le ka har'a cynomolgus macaques (n = 20). Ha litšoene li ne li sa tšoane nakong ea bolulo ka bomong, matlo a sechaba a ekelitse palo kapa ho fumaneha ha li-receptor tsa dopamine D2 ho litšoene tse hlahelletseng mme ha li hlahise phetoho litšoene tse tlaasana. Liphetoho tsena tsa neurobiological li bile le tšusumetso ea bohlokoa boitshwarong joalo ka ha ho bonts'itsoe ke ho fumana hore cocaine e sebetsa e le se matlafatsang ho litšoene tse tlase empa eseng tse matla. Lintlha tsena li bonts'a hore liphetoho tikolohong ea mmele li ka hlahisa liphetoho tse tebileng tsa bioloji tse nang le mekhatlo ea bohlokoa ea boits'oaro, ho kenyeletsoa le tlokotsi ea ho lemalla koae.
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