mohloli o moholo
Bernard B. Brodie Lefapha la Neuroscience le Setsi sa Botle bakeng sa Neurobiology of Addictions, Univesithi ea Cagliari, Italy.
inahaneloang
The dopamine D₃ e khethang agonist pramipexole (50 ng) e susumetsang penile erection le ho lutla ha ho kenngoa kahare ho kutu ea patsi ea hypotalamus ea litoeba tse tona, joalo ka motsoako oa D₁ / D₂-agonist apomorphine (50 ng), ha D₄ agonist PD 168,077 (100 ng) penile erection feela. Likarabo tsena li ile tsa tšoarella bakeng sa metsotso ea 45-60 mme li bile teng ka keketseho ea li-NO₂- le tse ling tsa NO concent- ho li-dialysate tse fumanoeng ho tloha penventricular nucleus ka intracerebral microdialysis. Likarabo tsa Pramipexole le apomorphine li ile tsa fokotsoa ke D₂ tse khethollang mohanyetsi L-741,626 (5 μg), empa eseng ke D₃ e khethollang mohanyetsi SB-277011A (10 μg), kapa D₄ e khethang mohanyetsi L-745,870 (5 μg). PVN pele ho dopamine agonist. Ka lehlakoreng le leng, likarabo tsa PD 168,077 li ile tsa fokotsoa ke L-745,870, empa eseng ka L-741,626 kapa SB-277011A. Pramipexole, apomorphine le PD 168,077 litlamorao le tsona li fokotsoe ke nitric oxide synthase inhibitor S-methyl-L-thiocitrulline (20 μg) le li-channels blocker tse itšetlehileng ka mofuta oa N²⁺ mofuta oa li-Ca²⁺ blocker ω-conotoxin (5 ng), tse fanoeng ka har'a nucleventricular nucleus, le ka oxytocin antagonist d (CH₂) ₅Tyr (Me) ²-Orn⁸-vasotocin (2 μg), e fuoe intracerebroventricularly empa eseng ka har'a nucleus ea potoloho dopamine agonists. Liphetho tsena li fana ka maikutlo a hore ho hlohlelletsoa ha D₂, empa eseng D₃ kapa D₄ receptors, ke pramipexole kapa apomorphine ho phahamisa tšubuhlellano ea Ca²⁺ mefuteng ea lisele tsa "oxytocinergic neurons". Sena se eketsa tlhahiso ea nitric oxide, e eketsang ts'ebetso ea methapo ea kutlo ea oxytocinergic libakeng tsa boko bo eketsehileng le methapo ea mokokotlo, e lebisang ho penile erection le ho longoa. Leha ho le joalo, ts'usumetso ea li-receptors tsa D₄ ka PD 168,077 le eona e eketsa tlhahiso ea Ca²⁺ protx / nitric oxide e lebisang ho penile erection, empa eseng ho ehola.
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