Eur J Neurosci. 2009 Dec 3; 30 (11): 2151-64. Doi: 10.1111 / j.1460-9568.2009.06999.x. Epub 2009 Nov 25.
Baskerville TA1, Allard J, Wayman C, Douglas AJ.
Dopamine le oxytocin li thehile likarolo karolong e bohareng ea regile erection ho likhoto; le ha ho le joalo, likarolo tsa neural tse amehang moelelong o itseng oa erectile le tšebelisano lipakeng tsa dopamine le methapo ea oxytocin li ntse li tlameha ho hlakisoa. Sebaka sa medial preoptic (MPOA), supraoptic nucleus (SON) le paraventricular nucleus (PVN) ea hypothalamus li ka sebetsa e le libaka tsa mokhethoa hobane li na le lisele tsa oxytocin, li amohela lipehelo tsa dopaminergic mme li bile le tšusumetso ho hlekefetsang bohlola. Double immunofluorescence e senotse hore lipalo tse kholo tsa lisele tsa oxytocin ho MPOA, SON le PVN li na le dopamine D (2), D (3) le D (4) receptors. Ho litoeba tse nang le bana, ho sebelisa khatello ea methapo e le sesupo sa 'mele ea ho emisa, blockade ea lumbosacral oxytocin receptors (UK, 427843) e fokotse likarabo tsa erectile ho dopamine agonist (apomorphine), e fanang ka maikutlo a hore dopamine e hapelle tsela ea patrate. Ho banna ba tsebang ntle le ho ba sieo ha mosali, penile erection e phahamisitsoeng ke D (2) / D (3) (Quinelorane) empa eseng D (4) (PD168077) agonist e ne e amana le ts'ebetso ea lisele tsa medial parvocellular PVN oxytocin. Teko e 'ngoe moo banna ba fuoeng phihlello e felletseng ho mosali ea amohelang, D (4) (L-745870) empa eseng D (2) kapa D (3) mohanyetsi (L-741626; nafadotride) inhibited penile erection (intromission), mme sena se ne se kopantsoe le ts'ebetso ea SON magnocellular oxytocin neuron.
Hammoho, data e fana ka maikutlo a litlamorao tsa dopamine liseleng tsa hypothalamic oxytocin nakong ea ha penile erection e ikhethile. Dopamine e ka sebetsa ka mefuta e fapaneng ea li-parvocellular le magnocellular oxytocin subpopulations ho hlahisa likarabo tsa erectile, ho latela hore na ts'oaetso e etsoa joang. Phuputso ena e bonts'a ho ba teng ha tšebelisano lipakeng tsa bohareng ba dopamine le litsela tsa oxytocin nakong ea penile erection, mme SON le PVN li sebetsa joalo ka libaka tsa kopanyo.
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