LITLHAHISO: Testosterone e kenngoeng potolohong ea moputso e putsa ka litsela tse ts'oanang le lithethefatsi tse lemalloang - ke testosterone e hlohlelletsang khetho ea sebaka se khethiloeng.
mohloli o moholo
Lefapha la Psychology, Univesithi ea New Orleans, Louisiana 70148, USA.
inahaneloang
Bopaki bo fetileng bo supa seo pherekano le intranucleus bokella liente of Testosterone e ba le litlamorao tse atlehang ho likhoto tsa banna joalo ka ha li lekantsoe a e hlophisitsoeng sebaka khetho (CPP) paradigm. Phuputso e teng hona joale e fuputse metheo ea methapo ea methapo e meholo ea Testosterone ka ho hlahloba phello ea pherekano le intranucleus bokella ente ea mohanyetsi oa dopamine receptor alpha-flupenthixol on Poleloana e reng of TestosteroneCPP e qapiloeng. Ka matsatsi a fapakaneng, likhoto tsa banna ba motho e moholo tsa Long-Evans li fumane pherekano liente of Testosterone mochini o kenyellelitsoeng metsi a qhibilihang ka hydroxypropyl-beta-cyclodextrin (HBC) (0.8 mg / kg) kapa saline-HBC hang-hang pele a koalloa 30 min ho e ngoe ea likarolo tse peli tsa sebaka khetho lisebelisoa. Likhoto tsohle li amohetse matsatsi a li-8 tsa li-pairings (li-pair tsa li-hormone, li-pair tsa saline tse 'ne). Letsatsing la 9 likhoto li fuoe seboka sa liteko tsa 20-min nakong eo li neng li khona ho fumana likarolo tsohle tsa lisebelisoa. Ha ho na hormone e ileng ea kenngoa pele ho nako ea tlhahlobo; leha ho le joalo, likhoto li amohetse a pherekano (Metsotso ea 20 pele; 0.2, 0.3 mg / kg) kapa intra-bokella (Metsotsoana ea 2 pele, 5.0 micrograms) ente of alpha-flupenthixol kapa letsoai. Ka letsatsi la liteko, likhoto li amohela letsoai liente o qetile nako e eketsehileng a le phapusing eo pele e neng e raloa le liente of Testosterone ho feta ka phapusing e neng e kentsoe koloi pele liente. Ka lehlakoreng le leng, litoeba tse amohelang pherekano or intra-bokella alpha-flupenthixol liente Ha a qeta nako e ngata haholo kamoreng eo pele e neng e raloa le Testosterone. The blockade ea Testosterone CPP e ne e se ka lebaka la phello ea alpha-flupenthixol mabapi le boits'oaro ba koloi. Se fumanoeng se fana ka bopaki bo eketsehileng ba thepa e ruisang Testosterone mme o bontshe seo pherekano tsamaiso le intra-bokella tsamaiso ea alpha-flupenthixol le literata Poleloana e reng of Testosterone CPP. Melemo e ruisang molemo ea Testosterone li arolelanoa, bonyane ka karolo, ka ho sebelisana le sisteme ea mesolimbic dopamine.
;
