Molao oa Testosterone oa thobalano ea steroid e amanang le li-mRNA le li-mRNA tse amanang le dopamine tse lilemong tsa bohlankana ba ratang rat substantia nigra (2012)

Tertia D Purves-Tyson, David J Handelsman, Kay L Double, Samantha J Owens, Sonia Bustamante le Cynthia Shannon Weickert

BMC Neuroscience 2012, 13:95 doi: 10.1186 / 1471-2202-13-95

E phatlalalitsoe: 6 Phato 2012

inahaneloang

Background

Keketseho e eketsehang ea schizophrenia ho ba batona ba lilemong tsa bocha e bontša hore khokahano pakeng tsa nts'etsopele ea dopamine e amanang le psychopathology le liphetoho tsa kelello tse tsamaisoang ke testosterone li ka ba teng. Leha ho le joalo, liphapang tsa hore na testosterone e eketsa kapa ea fokotseha dopamine neurotransication lia fumanoa na lithuto tse ngata li rarolla potso ena ho liphoofolo tse kholo. Ketso e itšetlehileng ka testosterone ho li-neuron e otloloha ka ho qaqisa li-androgen receptors (AR) kapa ka ho sa tobang ka phetoho ho 17beta-estradiol le ts'ebetso ea li-estrogen receptors (ER). Li-neurop tsa dopamine tsa "midbrain" li arabela joang ho li-steroid tsa thobalano ho latela ho ba teng ha thobalano ea li-sexid receptor (s) le boemo ba li-enzymes tsa steroid (aromatase le 5alpha-reductase). Re ile ra etsa lipatlisiso tsa hore na gonadectomy le ho ts'oaroa ka thobalano ka steroid ho ka susumetsa maemo a dopamine ka ho fetola liprotheine tsa tyrosine hydroxylase (TH) le mRNA le / kapa dopamine senya enzyme mRNA [catechol-O-methyl transferase (COMT) le monoamine oxygenase (MAO) A le B] ka tekanyo e motona e motona e motona substantia nigra. Re kholoa hore testosterone ea lilemong tsa bocha e ne e tla laola li-steroid tsa thobalano ka ho laola li-mRNA tsa ER le tsa AR le ka modulation ea aromatase le litekanyetso tsa 5Rpha-reductase mRNA.

Results

Re fumana ERalpha le AR ka har'a "midbrain dopamine neurons" litekong tsa banna ba lilemong tsa bocha, ho bonts'a hore li-neurop tsa dopamine li ikemiselitse ho arabela li-steroid tsa thobalano tse potileng. Re tlaleha hore androgens e eketsa protheine ea TH mme e eketsa li-COMT, MAOA le MAOB mRNA ho monna e motona ea lilemong tsa bocha. Re tlaleha hore li-steroid tsohle tse tharo tsa thobalano li eketsa AR mRNA. Ketso e khethollang litseleng tsa ER, tse nang le ERalpha mRNA tlase-regulation le ERbeta mRNA up-regulation ka testosterone li fumanoe. 5alpha reductase-1 mRNA e ile ea eketsoa ke ts'ebetso ea AR, mme aromatase mRNA e fokotsehile ke gonadectomy.

Nahanisisa

Re fihlela qeto ea hore testosterone e eketsehang bocheng e ka fetolela tekatekano ea lipontšo tsa steroid ea thobalano ho amohela likarabo tsa androgenic ka ho khothaletsa phetoho ea T ho DHT le ho eketsa AR mRNA. Ho feta moo, testosterone e ka eketsa sebopeho sa dopamine ea lehae le metabolism, ka tsela eo ea fetola molao oa dopamine kahare ho nigra eaantiene. Re bontša ketso eo ea testosterone ka bobeli ba li-AR le li-ERs modulates synthesis ea thobalano ea steroid ka ho fetola maemo a AR le ER mRNA maemong a tloaelehileng a botona ba botšehali a fetohang banna. Ho eketseha ha li-steroid tsa thobalano bokong nakong ea bocha ho ka fetola litsela, ho eketsa tlokotsi bakeng sa nts'etsopele ea psychopathology.