Int J Androl. 2011 Dec 13. Doi: 10.1111 / j.1365-2605.2011.01230.x.
Nyante SJ, Graubard BI, Li Y, McQuillan GM, Platz EA, Rohrmann S, Bradwin G, McGlynn KA.
mohloli o moholo
Karolo ea Epidemiology ea Kankere le Liphatsa tsa lefutso, Setsi sa Kankere ea Naha, Bethesda, MD Lefapha la Lipalo, Univesithi ea Texas ho Arlington, Arlington, TX Setsi sa Naha sa Lipalopalo tsa Bophelo, Hyattsville, MD Lefapha la Epidemiology, Sekolo sa Johns Hopkins Bloomberg sa Bophelo ba Sechaba, Johns Hopkins Univesithi, Baltimore, MD, USA Karolo ea Kankere ea Epidemiology le Thibelo, Setsi sa Bongaka le Thibelo ea Bongaka, Univesithi ea Zurich, Zürich, Switzerland Lefapha la Bongaka ba Bongaka, Sekolo sa Bongaka sa Harvard le Sepetlele sa Bana, Boston, MA, USA.
inahaneloang
Liphuputso tse fetileng li bontša hore li-testosterone tsa banna li theohile ha nako e ntse e tsamaea. Ho fumana sena ho palo e kholo ea batho ba Amerika, re ile ra hlahloba liteko tsa testosterone tsa mahala ho National Health and Nutrition Examination Surveys (NHANES) ho tsoa 1988-1991 le 1999-2004. Re boetse re hlahlobile globulin e tlamang li-hormone tsa thobalano (SHBG), estradiol le androstanediol glucuronide (3α-diol-G) ka nako e ts'oanang. Banna ba basoeu ba Ma-Hispanic ba basoeu, bao e seng ba Hispanic, le ba Mexico le Amerika ba tsoang 1988-1991 le 1999-2004 lipatlisiso tsa NHANES tse neng li le lilemo tse 20 'me li na le serum ho tloha ha mali a tsoa hoseng li kenyelelitsoe tlhahlobisong ena (1988-1991: N = 1,413; 1999-2004: N = 902). Testosterone, estradiol le SHBG li ne li lekantsoe ke li-immunoassays tsa tlholisano tsa electrochemiluminescence mme 3α-diol-G e ne e lekantsoe ke enzyme immunoassay. Testosterone ea mahala e ne e baloa ho sebelisoa litekanyetso tsa testosterone le SHBG. Mefuta e fetotsoeng ea li-hormone e ne e hakanngoa hore e sebelisa mokhoa o ts'oanang, ho ikarabella bakeng sa litekanyo tsa sampuli tsa NHANES le boqapi, lilemo, morabe / morabe, index ea boima ba 'mele, selikalikoe sa letheka, ts'ebeliso ea joala le ho tsuba. Ho ile ha baloa liphapang tsa li-concentrations tse fetotsoeng (Δ) le li-p-values tse mahlakore a mabeli; p <0.05 e ne e le bohlokoa lipalo-palo. Ka kakaretso, 3α-diol-G le estradiol li fokotsehile lipakeng tsa 1988-1991 le 1999-2004, empa ho bile le phetoho e nyane ho testosterone, testosterone ea mahala, kapa SHBG (Δ: 3α-diol-G = -1.83 ng / mL, p <0.01 ; estradiol = -6.07 pg / mL, p <0.01; testosterone = -0.03 ng / mL, p = 0.75; testosterone ea mahala = -0.001 ng / mL, p = 0.67; SHBG = -1.17 nmol / L, p = 0.19) . Stratification ka lilemo le morabe e senotse hore SHBG le 3α-diol-G li fokotsehile har'a makhooa a lilemo tse 20-44 (Δ: SHBG = -5.14 nmol / L, p <0.01; 3α-diol-G = -2.89 ng / mL, p <0.01) le testosterone ea mahala e eketsehile har'a batho ba batšo ba lilemo li 20-44 (Δ: 0.014 ng / mL, p = 0.03). Estradiol e fokotsehile har'a lilemo tsohle tsa makhooa le Maamerika a Mexico.
Qetellong, ho ne ho se na bopaki ba ho fokotseha ha testosterone pakeng tsa 1988-1991 le 1999-2004 ho baahi ka kakaretso ba US. Tlhahlobo ea subgroup e fana ka maikutlo a hore SHBG le 3cy-diol-G li theohile ho banna ba basoeu ba basoeu, estradiol e fokotsehile ho banna ba basoeu le ba Mexico le Amerika, 'me testosterone ea mahala e eketsehile ho banna ba batšo ba batšo. Liphetoho tsena li ka amana le ho ata ha mathata a ho ba le bana ho bahlankana.
© 2011 Bangoli. Koranta ea Machabeng ea Andrology © 2011 European University of Andrology.
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