Lipatlisiso tsa Boithuto ba Boits'oaro
E fumaneha inthaneteng 28 November 2016
Lintlha-khōlō Tsa
• GABAA li-receptors li laola ka mokhoa o fapaneng ho latela boemo ba thobalano.
• Systemic bicuculline e tlosa ho satiety ka thobalano, empa e ha le na litlamorao ho likhoto tsa banna tse etsang thobalano.
• Intra-VTA bicuculline e etsa hore ho kopitsoe ho litšoelesa tse tona tsa banna ka thobalano.
• GABA e laola boitšoaro ba setho sa botona ba botona le botšehali ho ba VTA
inahaneloang
Ho fetisoa ha GABAergic sebakeng sa "ventral tegmental" (VTA) ho na le tšusumetso ea tonic inhibitory mosebetsing oa mesolimbic dopaminergic neurons. Blockade ea VTA GABAA li-receptors li eketsa ho lokolloa ha dopamine ka li-nucleus accumbens (NAcc). Keketseho ea maemo a NAcc dopamine hangata e tsamaisana le pontšo ea boits'oaro ba thobalano. Ho ikopanya le satiety ho khetholloa ka ho kenya ts'ebetsong nako e telele (72 h) thibelo ea boits'oaro ba thobalano mme sistimi ea mesolimbic e bonahala e nka karolo ketsahalong ena. Phetiso ea GABAergic ho VTA e kanna ea nka karolo ho boloka boemo bona bo tšoarellang ba thobalano. Ho leka khopolo-taba ena, mosebetsing oa rona re batlisisitse phello ea GABAA receptor blockade ho banna ba khathetseng thobalano 24 h kamora ho kopantsoe le ho khora, hang ha boemo ba thobalano bo thehiloe, mme ba e bapisa le phello ea eona ho likhoto tse nang le boiphihlelo ba thobalano. Liphetho li bonts'itse litekanyo tse tlase tsa bicuculline tse laoloang ka mokhoa o ts'oanang le boits'oaro ba thobalano ka likhoto tse felileng ka thobalano, empa li haelloa ke phello ea ho kopitsa liphoofolo tse nang le boiphihlelo ba thobalano. Ho kenella ha li-intra-VTA tse peli tsa bicuculline ha hoa ka ha fetola boitšoaro ba thobalano ba likhoto tse nang le boiphihlelo ba thobalano, empa ho susumetsa boits'oaro ba thobalano ho banna bohle ba khathetseng thobalano. Kahoo, GABA e bapala karolo ea taolo ea boits'oaro ba thobalano ho VTA. Ho tšohloa karolo e phethoang ke phetiso ea GABAergic lipontsong tsa boits'oaro ba banna tsa liphoofolo tse nang le maemo a ikhethileng a thobalano.
Keywords
- GABAA li-receptors;
- bicuculline;
- VTA;
- thibelo ea thobalano;
- satiety;
- boits'oaro ba monna;
- sistimi ea mesolimbic;
- ho arabela ka thobalano
;
