Ho sebelisana pakeng tsa nitric oxide le phetoho ea dopaminergic ho laola tsela ea penile erection. (2011)

LIQOLE: Liphetoho li kenyelletsa ts'ebetso ea li-receptor tsa D1 liseleng tsa penile.

 

mohloli o moholo

Lefapha la Pharmacology & Toxicology, Faculty of Pharmacy, Univesithi ea Alexandria, Alexandria, Egypt. [imeile e sirelelitsoe]

inahaneloang

E le karolo ea karolo ea dopamine ka har'a poelano ea penile erection e sa tsoa sibolloa, karolo ea eona e ka bang teng modulong ea ketso ea NO le hore na li-receptors tsa D1 kapa D2 li kentse letsoho phetolelong ena e ka bang teng. Ho ile ha sebelisoa mokhoa o ikemetseng oa bo-rabi Corpus cavernosum le boholo ba khatello ea intracavernosal ka har'a mofuta oa li-anesthetised rat. D1 antagonist SCH23390 empa eseng D2 antagonist sulpiride e theotse phello ea Nhibitory ea N (G) -nitro-L-arginine (L-NNA) le phello e matla ea sildenafil ho likarabo tsa erectile. L-NNA ha ea ka ea fetola phello ea inhibitory ea SCH23390 kapa phello e bakoang ke apomorphine empa e ntlafalitse phello ea fenoldopam ea tekanyetso e phahameng ho khatello ea intracavernosal. Ka mokhoa o ts'oanang, fenoldopam e hlahisitse 47.30 ± 6.89% ts'ehetso ea boikhathollo ba corpus cavernosum ntle le ts'ebeliso ea L-NNA le 80 ± 9.34% e teng boteng ba eona ho 3 Hz. Tšusumetso ea sildenafil e ile ea fokotsoa haholo ka ho etsa boitlamo le SCH23390 kapa sulpiride mme ea felisoa ka botlalo ke ho kopana ha bona. Boithuto bona bo tšehetsa karolo e bapaloang ke li-receptors tsa D1 ka mokhoa o poteletseng taolong ea penile erection. Ho ba sieo ha NO ho kanna ha ama phello ea li-receptor tsa D1 ho tsogelwa. Ts'ebetso ea li-receptor tsa D1 e kanna ea kenya letsoho ho kopanngoeng ha NO ho Corpus cavernosum kapa e ka kenya letsoho karolo ea NO ho tsogelwa.

© 2010 The Author Fundamental and Clinical Pharmacology © 2010 Société Française de Pharmacologie et de Thérapeutique.