Pharmacol Biochem Behav. 2013 Oct 12. pii: S0091-3057 (13) 00238-4. Doi: 10.1016 / j.pbb.2013.10.004.
Bijlsma EY, Chan JS, Olivier B, Oa JG, Millan MJ, Waldinger MD, Ho lebala RS.
mohloli o moholo
Setsi sa Utrecht bakeng sa Saense ea Mahlale a Bongaka le Setsi sa Rudolf Magnus sa Neuroscience, Univesithi ea Utrecht, Sorbonnelaan 16, 3584CA Utrecht, Netherlands.
inahaneloang
Ho hlobaela ha thobalano le litakatso tsa botona kapa botšehali ho ama boleng ba bophelo ba basebelisi ba khatello ea maikutlo le ho fokotsa ho latela kalafo. Mefuta ea liphoofolo e fana ka mokhoa o rutang oa ho hlahloba litlamorao tse ka bakoang ke thobalano ea lithethefatsi tsa noha. Tlhahlobo ena e bua ka botsitso le ho hlahisa boikoetliso ba rona bo tšoanang ba tlhahlobo ea tlhahlobo e mpe, e tlase le e sa foleng ea li-compact tsa psychoactive tlhahlobo ea 30minute. Ntle le moo, re hlahisa kakaretso ea litlamorao tsa li-antidepressants tse fapaneng tsa boitšoaro ba setho sa botona ba botona, joalo ka ha ho lekoa mo maemong a rona a liteko a lekanang. Ka ho bapisa litlamorao tsa li-antidepressants tsena tse ikhethileng (paroxetine, venlafaxine, lupropion, buspirone, DOV 216,303 le S32006), tlhahlobo ena e bua ka ts'ebetso e tlamang ea litla-morao tsa thobalano le litlhare tsa bona tsa tlhaho.
Tlhahlobo ena e bonts'a hore boits'oaro ba thobalano bo thibeloa haholo ke li-antidepressants tse eketsang serotonin neurotransmission ka li-blockade tsa bajari ba serotonin, athe tseo haholoholo li eketsang litekanyetso tsa dopamine le noradrenaline li se nang litlamorao tsa thobalano. Ts'isinyeho eo ea thobalano e ke ke ea hlalosoa ka nako e le 'ngoe e eketseha ka methapo ea kutlo ea neuradraline, empa e etsoa ka mokhoa o tloaelehileng ka ho eketseha ha noradrenaline le dopamine neurotransmission. Ka hona, ho tšelisoa hore litlamorao tsa thobalano tsa li-inhibitors tse khethiloeng tsa serotonin li ka arolelanoa le litlamorao tsa bona tsa dopamine ho supa masekeng a boko ba thobalano. Kholiso ea bongaka ea li-antidepressants tsa lipalesa e lokela ho tsepamisa maikutlo ho tsona ka nako e le 'ngoe li eketsa serotonin le dopamine signaling.
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