Fetolela Psychiatry. 2013 Oct 1; 3: e308. Doi: 10.1038 / tp.2013.81.
Thorgeirsson TE, Gudbjartsson DF, Sulem P, Besenbacher S, Styrkarsdottir U, Thorleifsson G, Walters GB; TAG Consortium; Oxford-GSK Consortium; ENGAGE Consortium, Furberg H, Sullivan PF, Tlhakubele J, McCarthy MI, Steinthorsdottir V, Thorsteinsdottir U, Stefansson K.
mohloli o moholo
Decode genetics / AMGEN, Sturlugata 8, Reykjavik, Iceland.
Ho tsuba ho susumetsa boima ba 'mele hoo batho ba tsubang ba nang le bona ka tlase ho ba sa tsubeng le ho khaotsa ho tsuba hangata ho lebisa ho eketseheng ha boima ba' mele. Kamano lipakeng tsa boima ba 'mele le ho tsuba e hlalosoa ka mokhoa o itseng ke phello ea nicotine ho takatso ea lijo le metabolism. Leha ho le joalo, sistimi ea moputso oa boko e nka karolo taolong ea ho ja lijo le koae haholo.
Re ile ra lekola phello ea li-polymorphisms tsa single-nucleotide (SNPs) tse amang boima ba 'mele (BMI) mabapi le boitšoaro ba ho tsuba, mme ra leka 32 SNPs e fumanoeng tlhahlobisong ea meta bakeng sa ho hokahana le phenotypes tse peli tsa ho tsuba, ho qala ho tsuba (SI) le palo ea koae e tsuba ka letsatsi (CPD) ho batho ba tsubang ba Iceland (N = 34 216). E kopantsoe ho latela phello ea eona ho BMI, li-correlate tsa SNPs ka bobeli SI (r = 0.019, P = 0.00054) le CPD (r = 0.032, P = 8.0 × 10-7). Liphumano tsena li qaqisa lethathamong le leholo la bobeli la data (N = 127 274, e tsubang 76 242) bakeng sa SI (P = 1.2 × 10-5) le CPD (P = 9.3 x 10-5). Haholo-holo, tse fapaneng tse amanang haholo le BMI (rs1558902-A in FTO) ha lia ka tsa amahanya tloaelo ea ho tsuba. Kopano ea boitšoaro ba ho tsuba ha e bakoe ke phello ea li-SNPs ho BMI. Liphetho tsa rona li supa holima motheo o tloaelehileng oa tlhaho oa taolo ea takatso ea koae le lijo, ka hona tlokotsi ea ho lemalla tahi ea nicotine le botenya.
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