Nat Commun. 2020 Feb 7;11(1):782. doi: 10.1038/s41467-020-14458-y.
Domingo-Rodriguez L1, Ruiz de Azua ke2,3, Dominguez E4, Senabre E1, Serra I5, Kummer S1, Navanar M6, Baddennhausen S2, Hofmann C.2,7, Andero R8,9,10, Gerber S6, Navarrete M5, Dierssen M4,11, Lutz B2,3, Martín-García E1,8, Maldonado R12,13.
inahaneloang
Tlatsetso ea lijo e amana le botenya le mathata a ho ja mme e tšoauoa ka tahlehelo ea taolo ea boits'oaro le takatso e matla ea lijo. Mona, re sebelisa sebopeho sa khokahano ea "addiction" ea "cannabinoid" mofuta oa 1 ho "dorsal telencephalic glutamatergic neurons" e thibela nts'etsopele ea boits'oaro bo joalo ba ts'ebeliso ea lijo, e amanang le phetisetso e ntlafalitsoeng ea phepelo ea synaptic ho morial prefrontal cortex (mPFC ) le ho "nucleus accumbens" (NAc). Ka lehlakoreng le leng, thibelo ea chemogenetic ea ts'ebetso ea neuronal tseleng ea mPFC-NAc e etsa hore ho be le lijo tse qobelloang. Tlhahlobo ea Transcripttomic le liphatsa tsa lefutso li fumane hore polelo e eketsang ea dopamine D2 receptor tseleng ea mPFC-NAc e khothaletsa mofuta oa mofuta oa mofuta oa estotype. Boithuto ba rona bo senola mochine o mocha oa ts'ebetso ea methapo e thellang matla le ho ba tlokotsing ea nts'etsopele ea lithethefatsi tsa lijo, e leng se ka bulang tsela e kenang lipuisanong tse ncha le ts'ebetsong ea phepo ena.
PMID: 32034128
PMCID: PMC7005839
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