Biol Psychiatry. 2015 Dec 2. pii: S0006-3223 (15) 00996-8. Doi: 10.1016 / j.biopsych.2015.11.019.
Brown RM1, Kupchik YM2, Spencer S3, Garcia-Keller C4, Spanswick DC5, Lawrence AJ6, Simonds SE5, Schwartz DJ3, Jordane KA3, Jhou TC3, Kalivas PW3.
inahaneloang
LITLHAHISO:
Ho na le bopaki bo ntseng bo eketseha ba hore ts'oaetso ea ts'oaetso ea botona e tlatselletsang mofuteng o itseng oa botena e qobella tlhaho mme ka hona e na le likarolo tsa bothata bo lematsang. Leha ho le joalo, bopaki bo ikhethileng ba 'mele bo kopanyang botenya le synaptic polasetiki joalo ka se etsahetseng ka temallo bo haelloa. Re ne re batla ho tseba hore na boteng ba botenya bo khothalletsoang ke ho ja (DIO) bo amana le boits'oaro bo joalo ba boits'oaro, hammoho le mathata a amanang le ts'usumetso ea methapo ea methapo ea kutlo.
LITLHAHISO:
Likhoto tsa Sprague Dawley li ile tsa lumelloa ho fihlella mahala lijong tse matlafatsang bakeng sa libeke tsa 8 ebe li arotsoe ka phaello ea boima ho li-subgroups tse amanang le DIO le li-DIO. Ho fihlella lijo tse matlafatsoang ka nako eo ho ne ho thibetsoe feela ho linako tsa ts'ebetso ea tsamaiso ea letsatsi le leng le le leng ho sebelisa karolelano e tsitsitseng ea 1, 3, le 5 le kemiso e tsoetseng pele ea tekanyo. Kamora nako, methapo ea boko e bokelletseng masapo a bokong e ile ea lokisoa, mme ra leka liteko mabapi le karolelano pakeng tsa α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) le N-methyl-D-aspartate maqhubu le bokhoni ho bonts'a khatello ea maikutlo e telele.
LIKOTSO:
Re fumane hore tekanyo ea ho nts'etsopele ea DIO e hokahane le bofokoli ba bokhoni ba ho tsitsisa khatello ea maikutlo ea nako e telele ho li-nucleus accumbens, hammoho le ho eketseha ha bokhoni ho li-synapses tsena joalo ka ha li lekantsoe ke AMPA / N-methyl-D-aspartate maqhubu. Tumellanong le mathata ana, re bone boitšoaro bo kang ba lithethefatsi ho litheko tsa DIO-tse kenyelletsoeng, ho kenyeletsoa 1) khothatso e matla ea lijo tse fumanehang habonolo; 2) ho ja haholo; le 3) batla lijo tse eketsehileng ha lijo li sa fumanehe.
CONCLUSIONS:
Liphetho tsa rona li bonts'a phapang lipakeng tsa tekano ea DIO le liphetoho tse kopantsoeng le likarolo tsa boits'oaro bo bobebe, tse tšehetsang karohano e sa lekanyetsoang ea methapo ea kutlo ea bongoana bakeng sa tšebeliso e matla ea tahi le lithethefatsi.
LINKOTSO:
Tlatsetso ea lijo; Glutamate; Ho sithabela maikutlo ha nako e telele; Li-bokella tsa nyutlelie; Ho Nona Haholo; Synaptic polasetiki
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