Arch Gen Psychiatry. 2012 May;69(5):529-37. doi: 10.1001/archgenpsychiatry.2011.1586.
Grosshans M1, Vollmert C, Vollstädt-Klein S, Tlohile H, Leber S, Bach P, Bühler M, von der Goltz C, Mutschler J, Loeber S, Hermann D, Wiedemann K, Meyer-Lindenberg A, Mofumahali F.
inahaneloang
TLHOKOMELISO:
Ho na le lipuisano tse ntseng li tsoela pele ka methapo e amanang le lefu la kutlo. Le ha tsamaiso ea hypothalamic ea matla homeostasis ka lipontšo tsa endocrine e se e hlahlobiloe haholo, tsela eo karolo ea eona e amanang le moputso oa mesolimbic e emelang tšimo e ntle ea lipatlisiso tsa nako e tlang.
MORERO:
Ho lekola liphetoho tšebetsong ea ts'ebetso ea ts'ebetso ea ts'ebetso ea boko ho arabela methating e amanang le lijo ho hokahana le index ea boima ba 'mele (BMI; e lekantsoe ka boima ba li-kilograms e arotsoe ka bolelele ba limithara tse lekantsoeng) le plasma mahloriso a peptide leptin e laolang takatso ea lijo.
QETO:
Boithuto-lithutong
SETTING:
Setsi sa thuto le tlhekefetso ea kelello, Setsi sa Bohareng sa Bophelo ba Kelello, Mannheim, Jeremane.
KAROLO:
Lithuto tse mashome a mabeli a motso o le mong tse feteletseng (BMI> 30) le lilemo tsa 23- le lithuto tsa taolo ea nonobese tse lumellanang le thobalano (BMI 18.5-24.0) tse hiriloeng ke lipapatso.
LITLHAHISO TSE LING TSA HO FUMANA:
Ts'ebetso ea boko ea tikoloho (karabelo e itšetlehileng ka oksijene ea mali) ho arabela tlhahiso ea pono le kamano ea ts'ebetso ea boko le BMI le plasma leptin mahloriso.
LIKOTSO:
Likamano tse ntle tsa bohlokoa li ile tsa bonoa bakeng sa ts'ebetso ea ts'ebetso ea cue-e susumetsang ts'ebetso ea ts'ebetso ea methapo kahare ho kopanngoe le khatello ea plasma ea leptin (r = 0.27; P = .04) le BMI (r = 0.47; P = .001).
CONCLUSIONS:
Tlhahisoleseling e fana ka maikutlo a karolo ea mmele ea ho satiety mabaka a ho fetolela karabelo ea mekhahlelo ea mesolimbic ho lithahasello tsa lijo. Ntle le moo, mokhoa o fetotsoeng oa ho fana ka litlatsetso oa lapeng o ka hlalosang boitšoaro bo kang bokhoba le ho se khonehe ha bakuli ba batenya ho tloaela ho ja lijo le litlhoko tsa mmele.
PMID: 22566584
DOI: 10.1001 / archgenpsychiatry.2011.1586
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