Journal of Neuroscience, 20 May 2015, 35(20): 7964-7976;
doi: 10.1523 / JNEUROSCI.3884-14.2015
Letsatsi la Xue1,3, Nils B. Kroemer3,4,5, Maria G. Veldhuizen3,4, Amanda E. Babbs3, Ivan E. de Araujo3,4, Darren R. Gitelman3,6,7,8, Robert S. Sherwin9, Rajita Sinha4, le Dana M. Small1,2,3,4,10
inahaneloang
Li-rodents, li-food-predictive cues li etsa hore li je ka ho ba sieo ha tlala (Weingarten, 1983). Boitšoaro bona bo ferekanngoa ke ho tlosoa ha amygdala litsela ho ea lateral hypothalamus (Petrovich et al., 2002). Ho sa tsotellehe hore na potoloho ena e tlatsetsa nako e kae ea boima ba 'mele ha e tsejoe. Re sebelisa fMRI ho batho ba nang le bophelo bo botle ba 32, re bontša mona hore karabo ea amygdala ho latsoa lebese ha e sate empa e sa lapile e bolela esale pele phetoho ea boima. Phello ena e itšetlehile ka ho kopanela liphate, BMI ea pele, le ho phallela ka ho feletseng litekanyetso tsa ghrelin, empa e teng feela ho batho ba sa jereng kopi ea A1 allele ea polymorphism ea Taq1A.
Ka lehlakoreng le leng, bakhanni ba A1 ba fokolang, ba fokolisitseng boleng ba methapo ea D2 (Blum et al., 1996), bonts'a setsoalle se setle pakeng tsa ho arabela le boima ba 'mele. Leha ho le joalo, ho sa tsotellehe hore na li-genotype li na le eng, mohlala o matla oa causal modeling o tšehetsa lisebelisoa tsa unidirectional tse tsoang ho basolateral amygdala (BLA) ho hypothalamus litabeng tse satehileng.
Tlhaloso ena e fana ka maikutlo a hore, joalo ka litoeba, likarolo tse ka ntle li fumana monyetla oa ho potoloha lipotoloho tsa homeostatic tsa hypothalamus tsa motho ka tsela ea amygdala. Ka lehlakoreng le leng, nakong ea tlala, mekhoa e tloaelehileng ea ho kena hypothalamus le ho khanna likamano tse peli tsa bobeli le li-amygdala. Liphuputso tsena li hlahisa potoloho ea BLA-hypothalamic ho fetoha ha boima ba nako e telele e amanang le ho ja lijo tse sa tloaelehang le ho fana ka bopaki bo tiileng ba hore mekhoa e fapaneng ea boko e fana ka ts'oaetso ea ho theola boima bo itšetlehileng ka ho khetholla ha motho ka mong ho pontšo ea dopamine.
;
