Ho ja lijo tse nang le bothata ba ho ja le dopamine D2 receptor: li-genotypes le sub-phenotypes (2012)

Prog Neuropsychopharmacol Biol Psychiatry. 2012 Aug 7; 38 (2): 328-35. doi: 10.1016 / j.pnpbp.2012.05.002.

Davis C1, Levitan RD, Yilmaz Z, Kaplan AS, Carter JC, Kennethy JL.

inahaneloang

MORERO:

Ha ho ntse ho e-na le bothata ba ho ja lijo tsa ho itlopa joala (BED) ho fokotseha lilemong tse leshome tse fetileng, kutloisiso ea mehato ea eona ea neurobiological e ntse e le mekhahlelo ea pele. Phuputso e fetileng e bontša hore BED e ka 'na ea e-ba lefu la ho ja lijo tse tšoaetsanoang haholo le khethollo ea ho fumana moputso, le pontšo e matla ea dopamine meleng e tsamaisang menyaka le mekhoa e metle ea boitšoaro. Re ile ra batlisisa liphatsa tsa lefutso tsa D2 (DRD2 / ANKK1) le kamano ea bona le phantotype ea BED le li-sub-phenotypes tse 'nè tsa BED tse bontšang karabo e ntlafetseng bakeng sa tšusumetso e nepahetseng ea lijo.

LITLHAHISO:

Ka mohlala oa batho ba baholo ba 230 ba nang le BED le ntle le BED, re ipapisitse likarolo tse hlano tse sebetsang tsa mokelikeli oa D2: rs1800497, rs1799732, rs2283265, rs12364283 le rs6277, 'me ba hlahlojoa ho ja lijo, ho ja maikutlo, ho ja lijo tsa hedonic, ho fumanoa lipotso tsa lipotso tsa boipheliso.

LIKOTSO:

Ha e bapisoa le litsamaiso tse tsamaisanang le boima, BED e amana haholo le rs1800497 le rs6277 genotypes tse bontšang hore ho na le dopamine e ntseng e eketseha ka matla. Barupeluoa ba BED ba ne ba boetse ba se na monyetla oa hore ba nke mokhathala o monyane oa rs2283265. Lintlha tse tšoanang li amanang le sub-phenotypes tsa BED le rs1800497 e bontšang liphello tse matla ka ho fetisisa tataisong e boletsoeng esale pele.

CONCLUSIONS:

Phuputso ena e ts'ehetsa maikutlo a hore BED e kanna ea ba boemo bo bakiloeng ke ts'isinyeho ea ts'oaetso ho putsa - e leng monyetla o ka matlafatsang ho ja ho fetelletseng tikolohong ea rona ea hajoale ka phumaneho e ngata ea lijo tse ntlafalitsoeng tse nang le letsoai le leholo haholo.

PMID: 22579533

DOI: 10.1016 / j.pnpbp.2012.05.002