Ho ja lijo-thollo tse kang li-sucrose ho fokotsa bohlokoa bo putsang ba sucrose ka likhoto tse kholo (2018)

Physiol Behav. 2018 Jun 23. pii: S0031-9384 (18) 30384-6. doi: 10.1016 / j.physbeh.2018.06.027.

Smail-Crevier RL1, Mohlolo AC2, Hlatsoa SIJ2, Olmstead MC3.

inahaneloang

Ho itima lijo ka ho ja lijo ke boloetse bo tloaelehileng haholo ba ho ja, empa taba ea eona ea ho iphetola ha lintho ha e utloisisoe hantle. Batho le liphoofolo ba bontša ho ja lijo tse nang le lijo tse monate haholo, ho fana ka maikutlo a hore boitšoaro bo tsamaisoa ke litšenyehelo tsa lijo, ho e-na le lipontšo tsa homeostatic. Mokhoa oa lijo o laoloa, ka karolo e 'ngoe, ka mekhoa ea phekolo ea opioid e sa feleng, eo ka boeona, e ka fetoloang ke ho ja haholo. Re ile ra hlahloba khopolo ena ka ho hlahloba hore na li-stero-like-sucrose li ja joang ho ntlafatsa nts'etsopele ea sebaka seo ho khethiloeng ho sona (CPP) ho sucrose le morphine lipakeng tse peli tsa basali le banna. Lihlopha tse fapaneng li ile tsa fuoa intermittent (12h) kapa tse tsoelang pele (24 h) ho fihlella tharollo e monate (10% sucrose kapa 0.1% saccharin) le lijo matlong a bona a lehae ka matsatsi a 28. Ho kenyelletsa li-sucrose tse kenelletseng ho kenyeletsa ho itlosa joala, tse hlalosoang e le ho sebelisoa ho eketsehileng nakong ea hora ea pele; hoa bohlokoa, ho ja lijo tsa letsatsi le leng le le leng ho ne ho tšoana le lihlopha tse fihlang le tse kenang. Kamorong ea morao-rao, likhohlo tsohle li ile tsa hlahisa sebaka se khethiloeng sebakeng sa maemo (CPP) ho 15% sucrose ntle le litoeba tse tšehali tse fanoeng ka 12-h ho fihlela li-sucrose. Ka teko e fapaneng, lihlopha tsohle li bontšitse CPP ho morphine (4 mg / kg). Liphuputso tsena li bonts'a hore ho ja joala-joaloka sucrose ho ja, eseng feela ho sebelisoa ho sebelisoa, ho sitisa moputso oa ho sebetsa ntle le ho ama thuto ea moputso. Sena se lumellana le bopaki ba meriana ea boikaketsi ba boikarabello ho bakuli ba nang le bothata ba ho ja lijo tse itekanetseng.

LINKOTSO: BED; Ho fepa; Lijo tse tsitsitseng; Tšusumetso; Opiate

PMID: 29944859

DOI: 10.1016 / j.physbeh.2018.06.027