Mefuta e mengata ea ho itlopa joala ka Rats e hlophisitsoe ke Neuromedin U Receptor 2 ho Nucleus Accumbens le Ventral Tegmental Area (2019)

Metsoako. 2019 Feb 2; 11 (2). pii: E327. doi: 10.3390 / nu11020327.

Smith AE1,2, Kasper JM3,4; Ara 135, Anastasio NC6,7, Hommel JD8,9,10.

inahaneloang

Binge-eating disorder (BED) ke boloetse bo tloaelehileng ka ho fetisisa ba ho ja, bo khetholloang ka ho ja lijo tse nang le tatso e potlakileng khafetsa khafetsa ka nako e khuts'oane. BED e arolelana boitšoaro bo fetelletseng ba phenotype le botenya, e leng hape e hokahanngoang le tšebeliso e fetelletseng ea lijo tse monate haholo. Matla a matlafatsang a lijo tse hlabosehang haholo a buelloa ke li-nucleus accumbens (NAc) le sebaka sa ventral tegmental (VTA), se kentsoeng ts'ebetsong ea boits'oaro bo fetelletseng bo bonoang ho BED le botenya. Taolo e ka bang teng ea boits'oaro ba mofuta oa ho itlopa joala ke G protein-coupled receptor neuromedin U receptor 2 (NMUR2). Phuputso e fetileng e bontšitse hore tšebeliso e tlamang ea NMUR2 e ka sebelisa mofuta oa tšebeliso ea lijo tse nang le mafura a mangata. Re kopantsitse ts'ebeliso ea mofuta oa ho itlopa joala ka bongata ba metsoako e mengata ea mafura le lik'habohaedreite le polelo ea protheine ea synaptosomal NMUR2 ho NAc le VTA ea likhoto. Protheine ea Synaptosomal NMUR2 ho NAc e bonts'a kamano e matla le ho itlopa joala ka motsoako o "tlaase" -fat (khabohaedreite e phahameng), athe protheine ea synaptosomal NMUR2 ho VTA e bonts'a kamano e mpe e matla le ho itlopa joala "mafura" a mangata haholo. (0% k'habohaedreite) motsoako. Ha li kopantsoe hammoho, tlhaiso-leseling ena e fana ka maikutlo a hore NMUR2 e ka laola ka mokhoa o fapaneng ho ja mofuta oa binge ka hare ho NAc le VTA.

LINKOTSO: BED; NMUR2; ho kula ho tlōla; ho ja mefuta-futa; neuromedin U receptor 2; nucleus accumbens; botenya; sebaka sa ventral tegmental

PMID: 30717427

DOI: 10.3390 / nu11020327