Physiol Behav. 2012 Jun 6; 106 (3): 332-6. doi: 10.1016 / j.physbeh.2012.03.020.
mohloli o moholo
Univesithi ea Florida, College of Medicine, Lefapha la Psychiatry, Mokhatlo oa Bokooa oa McKnight, Gainesville FL 32610, United States. [imeile e sirelelitsoe]
inahaneloang
Le hoja li e-na le karolo e nyane feela ea li-neurons sebakeng seo, li-interneurons tse hlaselang ka har'a dorsal striatum li bonahala li phetha karolo ea bohlokoa ho laola mekhoa e fapa-fapaneng ea litakatso, ka karolo e itseng, ka ho sebelisana ha bona le lisebelisoa tsa mesolimbic dopamine (DA). Tlhahlobisong ena, re hlalosa lithuto tse bontšang hore mosebetsi oa li-interneurons tsa cholinergic nucleus accumbens (NAc) le lisebelisoa tse hlahisang likokoana-hloko sebakeng sa ventral tegmental (VTA) li ama boitšoaro ba phepo.
Ka vivo microdialysis lithuto likarolong li na le e senotse hore ho khaotsa ho ja ho amana le ho phahama ha maemo a acetylcholine (ACh) ho NAc. Ho kenyelletsa ACh ho tla thibela ho fepa, mme sena se boetse se amahanngoa le keketseho ea syntaptic accumulation of ACh. Ho feta moo, re tšohla kamoo, ho phaella mosebetsing oa bona qetellong ea lijo, li-interneurons tsa cholinergic tsa NAc li phetha karolo ea bohlokoa ho feleng ha tšebeliso ea lithethefatsi. Mokhoa o mong oa ho bolaea likokoana-hloko o amehang likarolong tse sa tšoaneng tsa boitšoaro ba ho khotsofatsa ke ho hlahisoa ho tloha ho pedunculpontine nuclei ka ho toba ho VTA. Ho kenya ts'ebetso ea tsamaiso ena ho ntlafatsa boitšoaro ka ho ts'ebetsong ha tsamaiso ea DA ea mahlo, le ho hanyetsa li-Ach receptors ho VTA ho ka fokotsa ho itokisetsa lithethefatsi. Qetellong, re buisana ka karolo ea ho bokella ACh boemong bo bobeli ba ho tlosoa ha lijo le lithethefatsi.
Liphuputso li senola hore li-accumbens ACh lia eketseha nakong ea ho tlohela lithethefatsi tse fapaneng tsa tlhekefetso (ho kenyeletsoa cocaine, nicotine le morphine). Ho phahama hona ha maemo a kantle ho lisele tsa ACh, hammoho le ho fokotseha ha maemo a kantle ho lisele tsa DA, ho lumeloa hore ho tlatsetsa ho boemo bo fetohelang, bo ka bonts'ang e le boits'oaro bo amanang le ho tlohela lithethefatsi. Khopolo ena e boetse e sebelisitsoe lipatlisisong tsa ho ja ho tlōla le / kapa "ho lemalla lijo," mme liphetho li fana ka maikutlo a ho se leka-lekane ho ts'oanang maemong a DA / ACh, a amanang le boits'oaro ba boits'oaro bo joalo ka lithethefatsi.
Ka kakaretso, li-neurons tsa cholinergic li phetha karolo ea bohlokoa ho feto-fetoha ha lijo le ho noa lithethefatsi, hammoho le likarolo tse fokolang tsa boitšoaro ba ho lemalla lijo le lithethefatsi.
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