Behav Brain Res. 2015 Sep 15; 291: 219-31. doi: 10.1016 / j.bbr.2015.05.030.
Bharne AP1, CD ea Borkar1, Subhedar NK2, Kokare DM3.
Lintlha-khōlō Tsa
- Mantsoe a "CART" a eketsa nakong ea ho itlopa joala ho bapisoa le boemo bo botle.
- Palo e phahameng ea 'mala kapa rimonabant e hloka ho fokotsa lijo tse kenang ka bongata.
- Ho tloaela ho itlopa joala ho etsa hore motho a se ke a tšoaroa ke lefu la "hyperhalamus" le "hippocampus".
- Litsela tse fapaneng tsa CART li tsamaisana le tlhahisoleseding ea satiety le moputso.
- Rimonabant e kenyelletsa anhedonia mme e fokotsa ho ja lijo tsa ho ja lijo ka ho sebelisa Mapolanka a AcbSh.
inahaneloang
Ho ja lijo tse ngata (BE) ho sitisa ho fepa le ho senya mekhoa ea moputso. Ho tloha ha cocaine le amphetamine e ngolisitsoeng peptide (CART) e kopanya satiety hammoho le moputso, karolo ea eona ho BE e lokafatsa lipatlisiso. Ho etsa hore BE, litoebe li fanoe ka mokhoa o thibelang ho fihlela lijo tse phahameng tse monate tse monate (HFSPD) bakeng sa nako ea libeke tsa 4. Tlaleho ea immunoreactivity ea likarolo tsa CART, le ho fapana le liphetoho tsa neuroplastic li ile tsa ithutoa ka boikokobetso le bohlophiso bo laola boko ba pelo. Ho feta moo, re ile ra batlisisa liphello tsa komiti, karete ea antibody kapa ea rimonabant ha motho a e-na le chow e tloaelehileng kapa HFSPD.
Li-HFSPD tse nang le li-rats li ile tsa bontša nts'etsopele ea BE-joaloka phenotype e bontšitsoeng ke ho sebelisoa ha HFSPD ka nako e khutšoanyane, e bontšang hore ho na le mekhoa e mengata ea ho thibela lefu lena. Bohareng ba ntlha, PART-immunoreactivity e ile ea eketseha haholo ho hypothalamic arcuate (ARC), lateral (LH), nucleus accumbens shell (AcbSh) le mokokotlo oa thalamus (PVT). Leha ho le joalo, bakeng sa nako e latelang ea 22-h, liphoofolo ha li bontše thahasello ho lijo, le polelo e tlaase ea CART.
Phekolo ea ho noa ka pele le rimonabant, lithethefatsi tse khothalletsoang ho phekoloa ha BE, li hlahisa anorexia, ho eketsa polelo ea CART ho ARC le LH, empa eseng ka AcbSh le PVT. Palo e phahameng ea MAP e ne e hlokeha ho hlahisa anorexia ka litoeba tse nang le bing. Ha liphuputso tsa neuronal li ntse li tiisitsoe ho netefatsa khokahano ea CART fiber ho tloha ho ARC le LH ho AcbSh, eketsa PART le synaptophysin ho itšireletsa mafung ka tsela ena li-rats tsa BE li khothalletsa ho matlafatsa khokahanyo ea CART.
Re etsa qeto ea hore potoloho e nang le ARC-LH-PVT-AcbSh ea potoloho ea potoloho e ka fetisa pontšo ea satiety ka tsela ea ARC-PVN ka li-rats.
LINTLHA TSE LENG TSEO: Ho ja lijo tse ngata; Cocaine- le amphetamine-e ngolisitsoeng peptide (MAP); Ho se itšepe; Matšoao-bohloko; Moputso; Satiety
PMID: 26008155
DOI: 10.1016 / j.bbr.2015.05.030