Brain Res Mol Brain Res. 2005 Apr 27;135(1-2):150-61.
Huang XF1, Yu Y, Zavitsanou K, Han M, Storlien L.
inahaneloang
Phuputso ea hajoale e hlahlobile boko ba dopamine D2 le D4 receptor le tyrosine hydroxylase (TH) polelo ea mRNA ho tse sa foleng tse nang le mafura a mangata a bakoang ke ho ja haholo (cDIO) le litoeba tse sa thibeleng (cDR). Litoeba tse mashome a mabeli a metso e robeli li fepiloe lijo tse nang le mafura a mangata (HF: 40% ea likhalori tse tsoang mafura) libeke tse 6 ebe li nkuoa e le cDIO (n = 8) kapa litoeba tsa cDR (n = 8) ho latela boima bo phahameng le bo tlase ba 'mele ba fumanang, ka ho latellana. Litoeba tse supileng li ile tsa fepuoa lijo tse mafura a tlase (LF: 10% ea likhalori tse tsoang mafura) 'me tsa sebelisoa e le taolo. Kamora libeke tse 20 tsa phepo, mafura a visceral ka grama ea boima ba 'mele ba pele a ne a phahame haholo sehlopheng sa cDIO (karolelano: 0.25, 0.09, le 0.04; P <0.01 cDIO vs. cDR le LF, ka ho latellana). Ho sebelisoa mekhoa e mengata ea li-hybridization in situ, maemo a D2 le D4 receptor le tyrosine hydroxylase (TH) mRNA a ile a lekanyetsoa likarolong tse ngata tsa boko. Litoeba tsa cDIO li ne li na le boemo bo phahameng haholo ba polelo ea D2 receptor mRNA mokokotlong oa li-nucleus accumbens (AcbC, + 16%) le likarolo tsa ventral tsa caudate putamen (CPu, 21% le 24%) ha li bapisoa le litoeba tsa cDR le LF. Methati ea polelo ea D2 receptor mRNA ho AcbC le karolo ea ventromedial ea CPu e ne e amana hantle le boima ba ho qetela ba mmele. Phuputso ena ke ea pele ea ho hlahloba ka mokhoa o hlophisehileng polelo ea D4 mRNA bokong ba toeba e sebelisa mokhoa oa hybridization. Phatlalatso ea D4 receptor mRNA ka har'a ventromedial hypothalamic nucleus (VMH) le karolo ea ventral ea lateral septal nucleus le eona e ne e le holimo haholo ho litoeba tsa cDIO ha li bapisoa le litoeba tsa cDR le LF (+ 31% le + 60%; P <0.05). Tlhaloso ea TH mRNA e ne e phahame haholo sebakeng sa teralal tegmental (+ 17%, P.
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