Dopamine le Opioid Neurotransmission in Mehavioral Addictions: Thuto ea PET e bapisanang le papali ea papali ea chelete le ho ja lijo tse nang le likokoana-hloko (2016)

Neuropsychopharmacology. 2016 Nov 24. Doi: 10.1038 / npp.2016.265.

Majuri J1,2,3, Joutsa J1,2,3, Johansson J3, Voon V4, Alakurtti K3,5, Parkkola R5, Lahti T.6, Alho H6, Hirvonen J3,5, Arponen E3,7, Khoele S3,7, Kaasinen V1,2,3.

inahaneloang

Le ha bokhoba ba boits'oaro bo arolelana likarolo tse ngata tsa kliniki le bokhoba ba lithethefatsi, bo bontša phapang e kholo haholo litekanyetsong tsa bona tsa boitšoaro (joalo ka papali ea chelete e sa laoleheng kapa ho ja). Ts'ebetso ea Neurotransmitter lithahasellong tsa boits'oaro ha e utloisisoe hantle empa e na le liphetho tsa bohlokoa ho utloisiseng kamano ea eona le mathata a ts'ebeliso ea lithethefatsi le mekhoa e sebetsang ea phekolo. Mona, re bapisa ts'ebetso ea opioid le dopamine lipakeng tsa litekanyetso tse peli tsa bokhoba ba ts'ebetso: papali ea papali ea methapo ea mafu (PG) le bothata ba ho ja ka mokhoa o itseng (BED).

Barupeluoa ba mashome a mararo a metso e robong (15 PG, 7 BED le 17 control) ba ile ba hlahlojoa ka [11C] carfentanil le [18F] fluorodopa positron emission tomography e sebelisa sekepe sa qeto e phahameng. Ho tlama hoa khoneha ho amanang le ho tlama ho sa tloseng (BP)ND) bakeng sa [11C] carfentanil le sekhahla sa protocol kamehla (Ki) boleng ba [18F] fluorodopa e ile ea hlahlojoa ka tlhahlobo-leseling ea voxel-by-voxel e mabapi le tikoloho.

Lithuto tsa BED li bonts'itse phokotso e pharalletseng ho [11C] carfentanil BPND libakeng tse ngata tsa mokokotlo oa subcortical le cortical [bokong]18F] fluorodopa Ki bapisoa le taolo. Ho bakuli ba PG, [11C] carfentanil BPND e fokotsehile ka mpeng ea kantle ho kantle le phapang ea [18F] fluorodopa Ki bapisoa le taolo. Ho li-bokellase tsa nucleus, karolo ea bohlokoa e kenyelletsang ts'ebetsong ea moputso, [11C] Carfentanil BPND e ne e le 30-34% tlase le [18F] fluorodopa Ki e ne e le tlase ka 20% ho BED ha e bapisoa le PG le litsamaiso (p <0.002). BED le PG ka hona ha li khone ho arohana e le tšebetso ea dopaminergic le opioidergic neurotransuction. Ha ho bapisoa le PG, bakuli ba BED ba bonts'a tahlehelo e atolositsoeng ea ho fumaneha ha li-mu-opioid receptor hammoho le bofokoli ba presynaptic dopaminergic.

Liphumano tsena li totobatsa tekanyo ea "heterogeneity" e tlatselletsang ho litekanyetso tse tlase tsa bokhoba ba tahi mme li bonts'a mekhoa e fapaneng pontšong ea boitšoaro le likarabelo tsa kalafo.

PMID: 27882998

DOI: 10.1038 / npp.2016.265