Khopolo-taba. 2010 Dec 15; 171 (3): 779-87. doi: 10.1016 / j.neuroscience.2010.09.046.
Alsiö J1, Olszewski PK, Norbäck AH, Gunnarsson ZE, Levine AS, Pickering C, Schiöth HB.
inahaneloang
Nucleus accumbens (NAcc) e kopanya moputso oa ho fepa; ketsahalo ea eona e bonts'a boleng ba tatso ea hedonic. NAcc dopamine e tataisa likarabo hanghang ho putsa, leha ho le joalo, ho nka karolo ha eona ho theheng likarabo tsa nako e telele kamora nako ea ho pepesetsoa lijo tse monate ha hoa hlalosoa. Ntle le moo, ho ja haholo ka lebaka la moputso ho etsa hore boima ba 'mele bo eketsehe, empa sekhahla sa boima ba' mele se its'etleha ho 'monono oa liphoofolo o atisang ho nona (OP) kapa -resistant (OR) phenotype. Ha ho hlake hore na karabelo ea NAcc dopamine lijong tse hlabosehang e its'etleha ho bonolo ba botenya.
Re ile ra batlisisa phello ea phekolo e sa thibeloang ho fihlela lijo tse phahameng tse mafura a tsoekere (HFHS) ho bonts'oa ha liphatsa tsa lefutso tse kenyang dopamine receptors mahakeng a NA le a OR le OR.Re hlahlobile ho phehella ha liphetoho tse entsoeng ka HFHS tse entsoeng ka D (1) le D (2) polelo ea liphatsa tsa OP le OR tse itšetlehileng ka ho tlosoa ha HFHS (bland chow bakeng sa matsatsi a 18).
Liphello tsa ho finyelloa ho fihlella HFHS ka ho fepa likhapha li ile tsa boela tsa ithutoa. Re sebelisa PCR (RT-PCR) reverse transcriptase, re fumane hore moriana oa NAcc D (1) o fokotsoe ka mor'a hore ho fihleloe HFHS nako e telele ho OP kapa OR liphoofolo. Phello e ile ea boela ea hlokomeloa ka mor'a matsatsi a 18 a ho tlosoa ha HFHS. Ho feta moo, HFHS e thibetsoeng e ile ea lebisa tlhokomelong ea D (1) hammoho le methapo ea mRNA ea D (2) ha e bapisoa le lithibelo tse fepehileng. Phapang pakeng tsa li-opioid receptor le NAcc le eona e ile ea fumanoa pakeng tsa lipotlolo tsa OP le OR nakong ea ho fumana lijo tse monate empa e se ka mor'a ho tlosoa.
Re etsa qeto ea hore ho pepa ha lijo tsa HFHS ho na le liphello tsa ka ho sa feleng bakeng sa tsamaiso ea NAcc dopamine, mohlomong ho fetola sepheo sa ho batla moputso oa lijo. Taba ea hore polelo ea NAcc D (1) e fetola liphoofolong tsa OP ka mor'a nako e telele ho pepeseha lijo tse monate le hore phello ena e fetela hantle karolong ea ho khaotsa ho fumana moputso, e kenyelletsa mokete oa D (1) mofuteng oa ho ja haholo 'me, ha e le hantle , fumana boima ba botenya bo botle ba batho ba tloaelehileng.
PMID: 20875839
DOI: 10.1016 / j.neuroscience.2010.09.046
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