Resin ea Boko. 2002 Oct 18;952(2):232-8.
Harrold JA1, Elliott JC, Morena PJ, Widdowson PS, Williams G.
inahaneloang
Agonists ho li-receptor tsa li-cannabinoid-1 (CB-1) li matlafatsa ho fepa mme haholo li ntlafatsa likarolo tsa moputso oa ho ja. Ho etsa lipatlisiso hore na li-cannabinoids tse ka bang teng li ka susumetsa takatso ea lijo tse hlabosehang, re bapisitse tšubuhlellano ea li-receptor tsa CB-1 bokong le hypothalamus, lipakeng tsa likhoto tse fepetsoeng chow (n = 8) le tse ling tse fuoang lijo tse hlabosang (n = 8) libeke tse 10 ho susumetsa botenya ba lijo. Boikarabello ba li-receptor tsa CB-1 bo fokotsehile haholo ka 30-50% (P <0.05) ho hippocampus, cortex, nucleus accumbens le nucleus ea entopeduncular ea likhoto tse fepehileng ka phepo.
Ho feta moo, bothata ba CB-1 bo fumanoang ka hippocampus, nucleus accumbens le nucleus entopeduncular e ne e amana haholo le ho ja lijo tse monate (r (2) = 0.25-0.35; tsohle P <0.05). Ka lehlakoreng le leng, mokelikeli oa CB-1 o tlamang hypothalamus o ne o le tlase ebile o sa fetoloe ka likhoto tse fepehileng ka phepo. Tsamaiso e tlase ea taolo ea CB-1 e tsamaellana le ts'ebetso e eketsehileng ea li-receptor tsena ka li-cannabinoids tse sa feleng. Ho sebetsa libakeng tse kang nucleus accumbens le hippocampus, tse kenyelletsang likarolong tsa hedonic tsa ho ja, li-cannabinoids li ka ba le takatso ea ho ja lijo tse monate 'me kahoo li lekanyetsa matla a ho fepa matla a matla le boima ba phepo e bakoang ke ho ja haholo. Leha ho le joalo, li-cannabinoids tsa hypothalamus ha li bonahale li susumetsa tšobotsi ena ea boitšoaro.
PMID: 12376184
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