Dynorphin / Kappa Opioid Receptor Signaling ka Mekhoa ea Preclinical ea Alcohol, Lithethefatsi le Lijo Tse lemalloang (2017)

Int Rev Neurobiol. 2017;136:53-88. doi: 10.1016/bs.irn.2017.08.001.

Karkhanis A1, Holleran KM1, Jones SR2.

inahaneloang

Sistimi ea dynorphin / kappa opioid receptor (KOR) e kenyelelitsoe "lehlakoreng le lefifi" la tahi, moo khatello ea maikutlo e eketsang likarabo tse mpe mabapi le ts'oaetso ea lithethefatsi le joala. Mohlala, khatello ea maikutlo e matla le ponahalo e matla ea ethanol li baka phahame ho dynorphin, e leng ligor e tsoelang pele ea KOR. Ts'ebetso ea li-KOR e fella ka phetoho ea li-neurotransmitters tse 'maloa; leha ho le joalo, khaolo ena e tla shebana le litlamorao tsa eona tsa taolo ho dopamine libakeng tsa mesolimbic. Ka ho khetheha, ts'ebetso ea KOR e na le tšusumetso e thibelang tokollo ea dopamine, ka hona e susumetsa ho sebetsoa ha moputso. Tsoseletso e phetoang ea li-KOR, ka mohlala, ka ho sebelisa lithethefatsi tse sa foleng le / kapa khatello ea maikutlo, e baka ts'ebetso e eketsehileng ea sistimi ea dynorphin / KOR. Keketseho ena ts'ebetsong ea KOR e suthisa botsitso ba homeostatic molemong oa phokotso e akaretsang ea ho paka ha dopamine ka ho fokotsa ho lokolloa ha dopamine kapa ka ho eketsa ts'ebetso ea Transporter dopamine. Khaolo ena e hlahloba litlamorao tsa ho pepeseha ha ethanol e sa foleng mosebetsing oa KOR le litlamorao tse tlase tsa phetisetso ea dopamine. Ntle le moo, litlamorao tsa ts'oaetso e sa foleng ea cocaine le litlamorao tsa eona ts'ebetsong ea KOR li tla hlahlojoa. Ho feta moo, li-KOR le tsona li ka nka karolo ho khanneng tšebeliso e fetelletseng ea lijo, ho kenya letsoho kotsing ea ho ba le botenya. Le ha liphuputso tse ling li bonts'itse hore bo-agonists ba KOR ba fokotsa tšebeliso ea lithethefatsi, lithuto tse ling li bonts'itse hore bahanyetsi ba fokotsa boits'oaro bo ts'oanang le bokhoba, ba bonts'a bokhoni ba kalafo. Mohlala, thibelo ea KOR e fokotsa ho kenella ha ethanol liphoofolong tse itšetlehileng ka eona, tšusumetso ea ho itšebelletsa k'hok'heine liphoofolong tse sa foleng tse pepesang khatello ea maikutlo le ts'ebeliso ea lijo ho liphoofolo tse nonneng. Khaolo ena e tla phenya-phenya mekhoa eo tsamaiso ea dynorphin / KOR e ka bang ea kalafo ka eona.

LINKOTSO: Ho lemalla; Cocaine; Dopamine; Dynorphin; Ethanol; Kappa mokelikeli oa opioid; Nucleus accumbens; Botenya; Khatello ea kelello

PMID: 29056156

DOI: 10.1016 / bs.irn.2017.08.001