Neuropharmacology. 2018 Mar 15; 131: 326-336. Doi: 10.1016 / j.neuropharm.2017.12.039. Epub 2017 Dec 29.
Derman RC1, Ferrario CR2.
inahaneloang
Boithuto ho batho bo fana ka maikutlo a hore likarabo tse matlafatsang tse susumetsang lithahasellong tsa lijo tsa Pavlovian li ka tsamaisa tšebeliso e feteletseng e lebisang ho ho boloka botenya, haholoholo ho batho ba kotsing. Leha ho le joalo, hore na khothatso ena e ntlafalitsoeng ea tšusumetso e hlaha ka lebaka la botenya kapa ho e-na le hoo e ka ba ha hoa tsebahala. Ho feta moo, leha lithuto tsa monahano oa batho li fane ka leseli la bohlokoa mabapi le karohano ea karabelo ea maikutlo pakeng tsa batho ba sa tsubang le ba sa tsubeng, mekhoa ea neural e sebelisang phapang ena ea boitšoaro ha e tsejoe. Nucleus Accumbens (NAc) mokena-lipakeng oa ho batla moputso le ts'ebetso ho NAc e matlafalitsoe liphoofolong tse kotsing ea ho ba motenya. Ka hona mona, re sebelisitse lithethefatsi tse thibelang botenya ho tlola le litoeba tse thibelang botenya ho hlahloba phapang e kholo ho khothalletso ea tšusumetso, le karolo ea NAc AMPARs polelong ea boits'oaro bona pele ho botenya. Re fumane hore litoeba tse atisang ho ba botenya li bonts'a ho batla lijo tse matla tse fetisitsoeng (Pavlovian-to-instrumental transfer, PIT). Re sebelisa infra-NAc infusions ea bahanyetsi ba AMPAR, re bonts'a hore boitšoaro bona bo khethollotsoe ka khetho ke li-CP-AMPARs mokokotlong oa NAc. Ntle le moo, datha ea biochemical e fana ka maikutlo a hore sena se bakoa ke karolo e 'ngoe ea keketseho e hlahisitsoeng ke Pono ea tikoloho ea CP-AMPAR ho NAc ea likotsi tsa botena. Ho fapana le hoo, lithetleng tse thibelang botenya PIT e ne e fokola ebile e sa ts'epahala 'me koetliso e sa holise polelo ea NAc AMPAR. Ka kopanelo, lintlha tsena li bonts'a hore litheko tsa lijo li ba le taolo e kholo ea khothatso ho batho ba batenya haholo-holo pele ho nts'etsopele ea botena. Sena se fana ka ts'ehetso mohopolo oa hore khothatso e matlafatsang ea ts'usumetso e ka ba karolo e tlatsetsang, ho fapana le phello ea botena. Ntle le moo, datha tsena li bonts'a karolo e nkiloeng ea boiphihlelo ba manane-thuto a NAc CP-AMPAR ho PIT, a supa lintlha tse ka bang teng pakeng tsa ts'ebetso lipakeng tsa lits'ebetso tse lebisang bokhobeng le boteng.
LINKOTSO: Recensor ea AMPA; Tlatsetso; Glutamate polasetiki; Ho susumetsa; PIT; Striatum
PMID: 29291424
DOI: 10.1016 / j.neuropharm.2017.12.039
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