Neuropsychopharmacology. 2015 May 6. Doi: 10.1038 / npp.2015.129.
Mancino S1, Burokas A1, Gutiérrez-Cuesta J1, Gutiérrez-Martos M1, Martín-García E1, Pucci M2, Falconi A2, D'Addario C3, Maccarrone M4, Maldonado R1.
inahaneloang
Pono e ntseng e eketseha e tiisa ho nona le ho ja ho feta tekano e le likhathatso tse amanang le lits'ebetso tse lemalloang tse ka arolelanang mekhoa e tloaelehileng ea methapo. Thutong ea hona joale, re ikemiselitse ho netefatsa mofuta oa phoofolo oa ho ja ka mokhoa o joalo-joalo ka litoeba, ho ipapisitse le ts'ebetso ea ts'ebeliso ea litheko tsa DSM-5, re sebelisa boemo bo sebetsang bo hlokometsoeng ke li-pellets tse tummeng haholo tsa chokolete. Bakeng sa sepheo sena, re lekotse ho phehella ha ho batla lijo nakong ea ho se fumane lijo, khothatso ea lijo le tiisetso ea ho arabela ha moputso o kopantsoe le kotlo. Moetso ona o lumelletse ho khetholla litlatsetso tse feteletseng tsa litoeba tse amanang le boits'oaro bo joalo ba bokhoba. Re entse lipatlisiso likhatisong tsena liphetoho tsa epigenetic le protheine. Phokotseho e kholo ea methapo ea methapo ea methapo ea methapo ea methapo ea methapo ea methapo ea methapo ea mali1 Morekisi oa mofuta oa liphatsa tsa lefutso o ile oa senoloa ka pele ho kotloloho ea litoeba tsa bokhoba ba joala, tse neng li hokahana le molao oa phetoho ea CB1 polelo ea protheine e sebakeng se le seng sa boko. "Pharmacological blockade" (rimonabant 3 mg / Kg; ip) ea CB1 receptor nakong ea thupelo ea morao-rao e fokotsitse liperesente tsa litoeba tse fihletseng litekanyetso tsa ho lemalla, tse lumellanang le ts'ebetso e fokotsehileng ea CB1 litoeba tse makatsang tsa thupelo ena e sebetsang. Liphuputso tsa Proteomic li sibolotse liprotheine tse hlalosoang ka mokhoa o fapaneng ka mokhoa o hlakileng maemong a bobebe kapa ho se lemosehe joalo ka boits'oaro ho hippocampus, striatum le preortalal cortex. Liphetoho tsena li ne li kenyelletsa liprotheine tse kenyelletsoang ho impulsivity joaloka-boits'oaro, polasetiki ea synaptic le cannabinoid signaling modulation, joalo ka alpha-synuclein, phosphatase 1-alpha, Doublecortin-like kinase 2 le diacylglycerol kinase zeta mme li ne li netefalitsoe ke immunoblotting. Moetso ona o fana ka sesebelisoa se hloahloa sa ho etsa lipatlisiso ka sebopeho sa methapo se ka fokolisang kotsi ea ho jella boits'oaro bo joalo ba ho ja.
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