Am J Physiol Regul Compact Comp Comp Physiol. 2002 Oct;283(4):R905-10.
Fetissov SO1, Meguid MM, Sato T, Zhang LH.
inahaneloang
Joalokaha ho senotsoe ke lithuto tse fetileng tsa microdialysis, lijo tse theotsoeng ka tlase tsa dopamine le lijo tse tsamaeang le dopamine li fapana haholo ho "hypothalamus" ea "monokotšoai" le litoeba tsa Zucker. Thutong ea hona joale, re fumane hore na li-receptor tsa dopaminergic le tsona li kengoa ke botenya.
Dopaminergic D (1) le D (2) polelo ea li-receptor mRNA e ile ea ithutoa sebakeng sa ventromedial hypothalamus (VMH), sebaka sa morao-rao sa hypothalamic (LHA), le adenohypophysis (AH) ea likhofu tsa lehlohlo le litheko tse sebelisang RT-PCR. Ho litoeba tsa Zucker tse feteletseng, re fumane keketseho ea DR (1) receptor mRNA ho VMH le AH le ho ngolisoa ka tlase ho LHA, athe D (2) receptor mRNA e ne e theotsoe ka bobeli ho VMH le LHA, empa ha e-so fetoloe ho AH , bapisoa le likhoto. Hape, keketseho ea li-receptor tsa D (1) e ile ea bonoa mokokotlong oa litoeba tse feteletseng ka immunohistochemistry. Re khethile VMH ho ea leka hore na ho na le liphetoho tse bonoang poleloeng ea dopamine receptor ea likhofu tse mpe tse khothalletsang tšusumetso ea boitšoaro ho dopamine joalokaha ho boletsoe ke hyperphagia. Likhoto tse sa fumaneng lijo tse fetang bosiu li ile tsa fumana ente e le 'ngoe ea VMH (10 nmol) ea sulpiride (D (2) receptor antagonist) kapa saline e le taolo, joale lijo li ile tsa fanoa' me phepelo ea lijo ea 1-h ea lekantsoe. Ts'oaetso ea lijo ka mor'a hore ente ea sodium e chesang e koahetsoe ke salineide e ne e le kholo ho litoeba tse batenya empa e ne e sa fapana ka likhoto.
Lintlha tsa rona li fana ka maikutlo a hore ho fokotseha ha "receptor" ea D (2) ho hypothalamus bonyane ho VMH induces boitšoaro bo khothalletsang ho ba le lijo tse kholo. Polelo ea receptor e tlase ea D (2) e kanna ea qobella ho lokolloa ha dopamine ka mokhoa o fetelletseng o hlokometsoeng ho litoeba tse ngata nakong ea ho kenella ha lijo le bakeng sa phello e matla ea karabelo ea dopamine. Tekanyo e phahameng ea D (1) polelo ea li-receptor ho VMH le e tlase ho LHA e kanna ea kenya letsoho mofuteng o khethehileng oa ho fepa lijaneng tsa makhopho tse emeloang ke boholo bo boholo ba lijo le palo e tlase ea lijo.
PMID: 12228060
DOI: 10.1152 / ajpregu.00092.2002
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